以大型单中心医院登记为基础的6 737例接受手术切除的胃癌患者的生存报告

沈洁; 王江立; 王泽洲; 莫淼; 周昌明; 袁晶; 徐大志; 郑莹

doi:10.19401/j.cnki.1007-3639.2024.03.004

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以大型单中心医院登记为基础的6 737例接受手术切除的胃癌患者的生存报告

专题论著 | 更新时间：2025-12-31

- 以大型单中心医院登记为基础的6 737例接受手术切除的胃癌患者的生存报告
- Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database
- 中国癌症杂志 2024年34卷第3期页码：268-277
- 作者机构：
  
  1. 复旦大学附属肿瘤医院肿瘤预防部，复旦大学上海医学院肿瘤学系，上海 200032
  2. 复旦大学附属肿瘤医院胃外1科，复旦大学上海医学院肿瘤学系，上海 200032
  3. 上海肿瘤疾病人工智能工程技术研究中心，上海 200032
- 作者简介：
  
  [ "沈洁（ORCID: 0000-0003-2504-4491），主管医师。" ]
  徐大志（ORCID: 0000-0002-2265-1272），主任医师、教授，复旦大学附属肿瘤医院胃外1科主任；
  [ "郑莹，复旦大学附属肿瘤医院肿瘤预防部主任，主任医师，教授，硕士研究生导师。长期从事肿瘤预防控制工作，涵盖肿瘤登记和监测、常见肿瘤社区防治干预、肿瘤筛查和早发现及肿瘤防治的健康教育和科普。开展肿瘤病因和预后研究，建立起了以人群为基础的乳腺癌患者队列和大肠癌筛查人群队列。执笔的《中国乳腺癌患者生活方式指南》旨在指导健康人群和癌症患者建立健康的生活方式。曾担任上海市重点公共卫生项目《社区居民大肠癌筛查项目》的技术负责人，组织编写和发布上海市抗癌协会《居民常见恶性肿瘤筛查和预防推荐》，为医疗机构和个人的癌症早发现和筛查提供指导。共发表学术论文100余篇，其中第一作者或通信作者发表90余篇，主编和参编20余部专著，获中华预防医学科技奖2项、上海市科技进步奖1项、上海医学科技奖1项、上海抗癌科技奖1项。主要学术兼职：上海市抗癌协会常务理事，上海市抗癌协会癌症预防与筛查专业委员会主任委员，中国抗癌协会乳腺癌专业委员会康复学组组长，中国临床肿瘤学会肿瘤大数据专家委员会常务委员，中国抗癌协会多原发和不明原因肿瘤专业委员会常务委员，中国抗癌协会乳腺癌专业委员会、科普专业委员会、肿瘤流行病学专业委员会、筛查和早诊早治专业委员会委员，中国控制吸烟协会控烟与肺癌防治专业委员会常务委员。" ]
- 基金信息：
  
  上海市加强公共卫生体系建设三年行动计划优青项目(GWVI-11.2-YQ37);上海市申康医院发展中心市级医院诊疗技术推广及优化管理项目(SHDC22022308)
- DOI：10.19401/j.cnki.1007-3639.2024.03.004
  中图分类号： R735.2
- 收稿：2024-01-18，
  
  修回：2024-03-10，
  
  纸质出版：2024-03-30
- 稿件说明：
移动端阅览
沈洁, 王江立, 王泽洲, 等. 以大型单中心医院登记为基础的6 737例接受手术切除的胃癌患者的生存报告[J]. 中国癌症杂志, 2024,34(3):268-277.

Jie SHEN, Jiangli WANG, Zezhou WANG, et al. Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database[J]. China Oncology, 2024, 34(3): 268-277.
沈洁, 王江立, 王泽洲, 等. 以大型单中心医院登记为基础的6 737例接受手术切除的胃癌患者的生存报告[J]. 中国癌症杂志, 2024,34(3):268-277. DOI： 10.19401/j.cnki.1007-3639.2024.03.004.

Jie SHEN, Jiangli WANG, Zezhou WANG, et al. Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database[J]. China Oncology, 2024, 34(3): 268-277. DOI： 10.19401/j.cnki.1007-3639.2024.03.004.

摘要

背景与目的：

收集以医院登记为基础的6 737例接受手术切除的胃癌患者的随访资料，分析其1、3和5年观察总生存（overall survival，OS）率和无病生存（disease-free survival，DFS）率，为中国的胃癌防控和政策制定提供真实世界研究证据。

方法：

纳入2015年1月1日—2020年12月31日在复旦大学附属肿瘤医院接受手术治疗的胃癌患者共6 737例，通过查阅患者病史了解患者的临床信息，并通过复诊病史、电话随访和死因数据链接等方式收集患者的生存随访资料，随访统计时间截至2023年11月30日。采用Kaplan-Meier法估计患者1、3和5年OS率和DFS率，并在不同年龄组、性别、治疗时期、肿瘤分期及病理学特征等亚组中分别描述。

结果：

接受手术切除的胃癌患者经中位50.99个月随访后，5年OS率和Ⅰ ~ Ⅲ期患者5年DFS率分别为70.37%和69.46%。Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期胃癌患者的5年OS率分别为94.32%、82.56%、51.01%和23.97%。不同年龄、部位、大体分型、Borrmann分型和Lauren分型的患者生存有显著差异。

结论：

肿瘤分期是影响胃癌患者生存的重要因素，应加强人群（尤其是高危人群）胃癌的筛查和早诊早治，进一步改善患者的生存。

Abstract

Background and purpose:

Follow-up data of 6 737 patients undergoing surgery for gastric cancer were collected based on hospital registration

and the 1-

3- and 5-years observed overall survival (OS) rates and disease-free survival (DFS) rates were analyzed to provide real-world research evidence for the prevention and control of gastric cancer and policy making in China.

Methods:

A total of 6 737 gastric cancer patients who underwent surgical treatment at Fudan University Shanghai Cancer center from 2015 to 2020 were included in this study. Clinical information and the follow-up endpoint data were collected through medical records review

telephone visits and death registry data linkage. The last follow-up date was November 30

2023

. Kaplan-Meier method was applied in evaluating the 1-

3- and 5-year OS rate and DFS rate

and survival data were described by different subgroups including age group

gender

treatment period

tumor staging

and pathological characteristics.

Results:

With a median follow-up time of 50.99 months

the 5-year OS rate of surgically resected gastric cancer patients was 70.37%

and 5-year DFS rate in Ⅰ-Ⅲ stage cases was 69.46%. The 5-year OS rates of stage Ⅰ

Ⅱ

Ⅲ and Ⅳ were 94.32%

82.56%

51.01% and 23.97%

respectively. The differences in survival among patients with different age

tumor location

gross classification

Borrmann classification and Lauren classification were significant.

Conclusion:

Staging is an important factor directly affecting the survival of gastric cancer patients. Screening and early diagnosis and treatment in large population

especially high-risk group

should be strengthened to further improve the patients’ survival.

关键词

Keywords

references

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