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177Lu-PSMA放射性配体疗法治疗前列腺癌的临床实践专家共识（2024年版）
Expert consensus of 177Lu-labeled PSMA radioligand therapy for clinical practice of prostate cancer (2024 edition)
- 中国癌症杂志 2024年34卷第7期 页码：702-714
- 作者机构：
- 作者简介：
- 基金信息：
DOI：10.19401/j.cnki.1007-3639.2024.07.010
中图分类号： R737.25收稿：2024-04-19，
修回：2024-06-07，
纸质出版：2024-07-30
- 稿件说明：
移动端阅览
中国抗癌协会肿瘤核医学专业委员会, 中国医师协会核医学医师分会. 177Lu-PSMA放射性配体疗法治疗前列腺癌的临床实践专家共识（2024年版）[J]. 中国癌症杂志, 2024,34(7):702-714.
Nuclear Medicine Committee of China Anti-Cancer Association Cancer, Association of Nuclear Medicine Physicians Chinese. Expert consensus of 177Lu-labeled PSMA radioligand therapy for clinical practice of prostate cancer (2024 edition)[J]. China Oncology, 2024, 34(7): 702-714.
中国抗癌协会肿瘤核医学专业委员会, 中国医师协会核医学医师分会. 177Lu-PSMA放射性配体疗法治疗前列腺癌的临床实践专家共识（2024年版）[J]. 中国癌症杂志, 2024,34(7):702-714. DOI： 10.19401/j.cnki.1007-3639.2024.07.010.
Nuclear Medicine Committee of China Anti-Cancer Association Cancer, Association of Nuclear Medicine Physicians Chinese. Expert consensus of 177Lu-labeled PSMA radioligand therapy for clinical practice of prostate cancer (2024 edition)[J]. China Oncology, 2024, 34(7): 702-714. DOI： 10.19401/j.cnki.1007-3639.2024.07.010.
摘要
镥-177标记前列腺特异性膜抗原放射性配体疗法（
177
Lu-labeled prostate-specific membrane antigen radioligand therapy，
177
Lu-PSMA-RLT）是一种通过精准地向前列腺癌细胞递送
177
Lu释放的β射线，引发肿瘤细胞DNA的辐射损伤从而杀灭肿瘤的创新治疗方法。现阶段国内外多个前列腺癌领域权威指南与共识推荐其用于治疗转移性去势抵抗性前列腺癌（metastatic castrate-resistant prostate cancer，mCRPC），国内尚未见关于
177
Lu-PSMA-RLT治疗前列腺癌的临床实践路径和用药规范的报道。本共识由中国抗癌协会肿瘤核医学专业委员会和中国医师协会核医学医师分会共同发起，结合现有的
177
Lu-PSMA-RLT注册研究结果、真实世界数据及国内外放射性核素临床治疗经验，根据牛津循证医学中心临床证据推荐等级和证据级别来评价不同级别的证据，在适应证、患者筛选、用药不良反应、随访和辐射安全等方面给出推荐意见。本共识旨在为临床医师提供
177
Lu-PSMA-RLT治疗前列腺癌的临床参考，为进一步制订行业相关指南奠定基础。
Abstract
177
Lu-labeled prostate-specific membrane antigen radioligand therapy (
177
Lu-PSMA-RLT) is an innovative treatment approach that precisely delivers β radiation emitted by
177
Lu to prostate cancer cells
causing radiation damage to the tumor cells’ DNA and thereby eliminating the tumor. At present
it has been recommended for the treatment of metastatic castrate-resistant prostate cancer (mCRPC) by many international and national authoritative guidelines and consensuses. However
there are no published clinical practice path and medication specifications for diagnosis and treatment in China. Therefore
the consensus was jointly
initiated by Cancer Nuclear Medicine Committee of Chinese Anti-Cancer Association and Chinese Association of Nuclear Medicine Physicians. Physicians from these two committees combined the existing results of
177
Lu-PSMA-RLT registration study
real world data domestic and international clinical experience of radionuclide treatment
and gave recommendations in terms of indications
screening adverse reactions
follow-up and radiation safety by taking different levels of evidence as reference according to clinical evidence levels and grades of recommendation from the Oxford Centre for Evidence-based Medicine. The purpose of this consensus was to provide physicians with reference for clinical application in the practice of
177
Lu-PSMA-RLT for the treatment of prostate cancer based on existing evidence and lay the foundation for the development of subsequent industry-related guidelines.
关键词
Keywords
references
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