1993—2023年国际儿童及青少年分化型甲状腺癌<sup>131</sup>I治疗文献计量分析

潘逸缙; 石聪; 孙郁青; 孙迪; 赵翊含; 彰金; 林岩松

doi:10.19401/j.cnki.1007-3639.2024.12.007

您当前的位置：

首页 >

文章列表页 >

1993—2023年国际儿童及青少年分化型甲状腺癌¹³¹I治疗文献计量分析

综述 | 更新时间：2025-12-31

- 1993—2023年国际儿童及青少年分化型甲状腺癌¹³¹I治疗文献计量分析
- Global trends of ¹³¹I-therapy for differentiated thyroid cancer in children and adolescents: a bibliometric analysis (1993-2003)
- 中国癌症杂志 2024年34卷第12期页码：1123-1133
- 作者机构：
  
  1. 中国医学科学院，北京协和医学院北京协和医院核医学科，疑难重症及罕见病国家重点实验室，核医学分子靶向诊疗北京市重点实验室，北京 100730
  2. 安徽医科大学第一附属医院核医学科，安徽合肥 230022
  3. 北京中医药大学东直门医院核医学科，北京 100700
- 作者简介：
  
  [ "潘逸缙（ORCID: 0009-0000-2870-2651），博士研究生。" ]
  林岩松（ORCID: 0000-0001-6095-4728），博士，主任医师、教授，中国医学科学院北京协和医学院北京协和医院核医学科副主任。
- 基金信息：
  
  中央高水平医院临床科研专项(2022-PUMCH-B-072);国家科技信息资源综合利用与公共服务中心开放基金(2024ST015)
- DOI：10.19401/j.cnki.1007-3639.2024.12.007
  中图分类号：
- 收稿：2024-08-02，
  
  纸质出版：2024-12-30
- 稿件说明：
移动端阅览
潘逸缙, 石聪, 孙郁青, 等. 1993—2023年国际儿童及青少年分化型甲状腺癌¹³¹I治疗文献计量分析[J]. 中国癌症杂志, 2024,34(12):1123-1133.

Yijin PAN, Cong SHI, Yuqing SUN, et al. Global trends of ¹³¹I-therapy for differentiated thyroid cancer in children and adolescents: a bibliometric analysis (1993-2003)[J]. China Oncology, 2024, 34(12): 1123-1133.
潘逸缙, 石聪, 孙郁青, 等. 1993—2023年国际儿童及青少年分化型甲状腺癌¹³¹I治疗文献计量分析[J]. 中国癌症杂志, 2024,34(12):1123-1133. DOI： 10.19401/j.cnki.1007-3639.2024.12.007.

Yijin PAN, Cong SHI, Yuqing SUN, et al. Global trends of ¹³¹I-therapy for differentiated thyroid cancer in children and adolescents: a bibliometric analysis (1993-2003)[J]. China Oncology, 2024, 34(12): 1123-1133. DOI： 10.19401/j.cnki.1007-3639.2024.12.007.

摘要

本研究通过文献计量学方法，对国际儿童及青少年分化型甲状腺癌（differentiated thyroid cancer in children and adolescents，caDTC）放射性碘131（iodine 131，

131

I）治疗领域的研究现状与发展趋势进行分析。检索 Web of Science Core Collection（WoSCC）数据库，检索时间限定为1993年1月1日—2023年12月1日，使用VOSviewer 1.6.20与CiteSpace 6.2.R6进行可视化分析。共计150篇文献符合本研究纳入标准，首篇发表于1994年;近30年来，caDTC

131

I治疗领域文献年发行量尽管自2020年以来略有下降，但整体上呈波动上升趋势;31个国家/地区涉足该领域，美国、意大利和中国的文献产出最多，全球合作网络分析显示欧美机构间合作相对更紧密;该领域期刊多为内分泌及代谢或儿科类别，

Thyroid

和

Journal of Clinical Endocrinology

Metabolism

具有重要影响力;2015年发表的《儿童甲状腺结节与分化型甲状腺癌诊治指南》（Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer）是总被引次数最多的文献;共计869名学者发表过该领域论文，高发文量学作者主要来自欧美地区，我国黄蕤学者上榜前十;聚类分析显示研究热点包括“metastasis（转移）”、“fusion oncogene（融合致癌基因）”、“late effects（迟发效应）”;关键词时序分析显示“

131

I”持续受关注时间最长，其他重要标签包括“management guidelines（管理指南）”、“ 2nd primary malignancy（第二原发恶性肿瘤）”及“term follow up（定期随访）”，涵盖

caDTC

131

I治疗的标准制定、疗效及不良事件监测等内容。当前在国际caDTC

131

I治疗领域，欧美地区占据主导地位，中国可依托患者群体规模优势加强国内外合作，以提升我国在该领域的研究影响力。在当前

131

I治疗仍待规范的情况下，聚类结果提示应尽快统一临床实践中的caDTC用

131

I治疗标准。未来该领域研究需关注术后

131

I治疗的疗效与安全性监测，深入探索

RET

融合等基因特征与

131

I疗效间的关联，寻找

131

I难治性caDTC的预测标志物，以期为临床上作出

131

I治疗的决策提供有力支持。

Abstract

This study aimed to delineate the characteristics and trends of scholarly publications within the domain of

131

I-therapy for differentiated thyroid cancer in children and adolescents (caDTC) through a bibliometric approach. A retrieval of publications concerning

131

I-therapy for caDTC from the Web of Science Core Collection (WoSCC) database was conducted

spanning from January 1993 to December 2023. Visualization analysis was performed utilizing VOSviewer 1.6.20 and CiteSpace 6.2.R6 software. A total of 150 English publications

including articles and reviews

were analyzed in this study

with the earliest work traced back to 1994. A fluctuating yet overall ascending trend in annual publication volume was observed over the three decades

with a slight recent downturn post 2020. The United States

Italy and China emerged as the most prolific contributors. International network mapping revealed robust collaboration predominantly between European and American entities. Journals featuring predominantly in this field were primarily categorized under endocrinology

metabolism or pediatrics

with

Thyroid and Journal of Clinical Endocrinology

Metabolism

recognized as highly influential. The "Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer"

published in 2015

was the most frequently cited document. A total of 869 scholars published literature in this field

with high-producing scholars mainly coming from Europe and the United States. Huang Rui from China was ranked among the top ten.

References and keywords clustering illuminated focal points of research such as “metastasis”

“fusion oncogene”

and “late effects”. The timelines viewer of keywords underscored enduring interest in “

131

I”

complimented by significant terms like “management guidelines”

“2nd primary malignancy”

and “term follow up”

encompassing standardization

efficacy

and surveillance of adverse events in

131

I-therapy for caDTC. The

131

I-therapy research for caDTC is largely steered by European and American efforts. China’s substantial patient demographic is positioned to enhance both domestic and international collaborative research. The current paucity of clinical standardization in

131

I-therapy for caDTC needs to be addressed. Future endeavors should be scrutinizing the short and long-term efficacy of

131

I-therapy of caDTC

probing into the relationship between molecular profiles such as RET fusion and the therapeutic effectiveness of

131

I-therapy

and pinpointiing efficacious biomarkers for

131

I-resistance

which are pivotal for informed decision-making in the therapeutic application of

131

I-therapy for caDTC.

关键词

Keywords

references

中国临床肿瘤学会核医学专家委员会 , 中国临床肿瘤学会甲状腺癌专家委员会 , 中国医疗保健国际交流促进会甲状腺疾病专业委员会 , 等 . 儿童及青少年分化型甲状腺癌核医学诊治中国专家共识(2022年版) [J ] . 中国癌症杂志 , 2022 , 32 ( 5 ): 451 - 468 . DOI: 10.19401/j.cnki.1007-3639.2022.05.011 http://doi.org/10.19401/j.cnki.1007-3639.2022.05.011

Expert Committee of Nuclear Medicine , Chinese Society of Clinical Oncology , Expert Committee of Thyroid Cancer , Chinese Society of Clinical Oncology , et al . Expert consensus on management of differentiated thyroid carcinoma in children and adolescents (2022 edition) [J ] . Chin Oncol , 2022 , 32 ( 5 ): 451 - 468 . DOI: 10.19401/j.cnki.1007-3639.2022.05.011 http://doi.org/10.19401/j.cnki.1007-3639.2022.05.011

KUHLEN M , WELLBROCK M , KUNSTREICH M , et al . Incidence and temporal patterns of differentiated thyroid carcinoma in children and adolescents in Germany: a pooled analysis based on data from the German malignant endocrine tumor registry and the German childhood cancer registry [J ] . Thyroid , 2024 , 34 ( 12 ): 1540 - 1550 .

ZHENG R S , CHEN R , HAN B F , et al . Cancer incidence and mortality in China, 2022 [J ] . J Natl Cancer Cent , 2024 , 4 ( 1 ): 47 - 53 .

DE SOUSA M S A , NUNES I N , CHRISTIANO Y P , et al . Genetic alterations landscape in paediatric thyroid tumours and/or differentiated thyroid cancer: systematic review [J ] . Rev Endocr Metab Disord , 2024 , 25 ( 1 ): 35 - 51 .

FRANCIS G L , WAGUESPACK S G , BAUER A J , et al . Management guidelines for children with thyroid nodules and differentiated thyroid cancer [J ] . Thyroid , 2015 , 25 ( 7 ): 716 - 759 . DOI: 10.1089/thy.2014.0460 http://doi.org/10.1089/thy.2014.0460

GUAN Q , WANG Y . Pathology features and clinical significances of thyroid carcinoma in children and adolescents [J ] . Chin J Pract Surg , 2022 , 42 ( 6 ): 638 - 43 .

BOUCAI L , ZAFEREO M , CABANILLAS M E . Thyroid cancer: a review [J ] . JAMA , 2024 , 331 ( 5 ): 425 - 435 . DOI: 10.1001/jama.2023.26348 http://doi.org/10.1001/jama.2023.26348

LIU Y J , WANG J F , HU X P , et al . Radioiodine therapy in advanced differentiated thyroid cancer: resistance and overcoming strategy [J ] . Drug Resist Updat , 2023 , 68 : 100939 .

PETERMANN-ROCHA F , DIAZ-TORO F , VALERA-GRAN D , et al . Bibliometric analysis of research on sarcopenic obesity: a review of scientific literature [J ] . Obes Rev , 2024 , 25 ( 9 ): e13784 .

SUN Z C , WANG X Y , XIAO J H , et al . Knowledge mapping and emerging trends in neural stem cell transplantation research for spinal cord injury: a bibliometric analysis (2004-2023) [J ] . Int J Surg , 2024 , 110 ( 12 ): 8215 - 8219 .

CHEN C M , SONG M . Visualizing a field of research: a methodology of systematic scientometric reviews [J ] . PLoS One , 2019 , 14 ( 10 ): e0223994 .

LIU X J , YUAN J Y , FENG Y F , et al . Knowledge graph and development hotspots of biochar as an emerging aquatic antibiotic remediator: a scientometric exploration based on VOSviewer and CiteSpace [J ] . J Environ Manage , 2024 , 360 : 121165 .

BOYACK K W , SMITH C , KLAVANS R . A detailed open access model of the PubMed literature [J ] . Sci Data , 2020 , 7 ( 1 ): 408 . DOI: 10.1038/s41597-020-00749-y http://doi.org/10.1038/s41597-020-00749-y

JOCHAM A , JOPPICH I , HECKER W , et al . Thyroid carcinoma in childhood: management and follow up of 11 cases [J ] . Eur J Pediatr , 1994 , 153 ( 1 ): 17 - 22 .

MU Z Z , ZHANG X , SUN D , et al . Characterizing genetic alterations related to radioiodine avidity in metastatic thyroid cancer [J ] . J Clin Endocrinol Metab , 2024 , 109 ( 5 ): 1231 - 1240 .

MU Z Z , ZHANG Y Q , SUN D , et al . Effect of BRAF V600E and TERT promoter mutations on thyroglobulin response in patients with distant-metastatic differentiated thyroid cancer [J ] . Endocr Pract , 2022 , 28 ( 3 ): 265 - 270 .

LEBBINK C A , LINKS T P , CZARNIECKA A , et al . 2022 European Thyroid Association guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma [J ] . Eur Thyroid J , 2022 , 11 ( 6 ): e220146 .

孙迪 , 孙郁青 , 张鑫 , 等 . 局部晚期或转移性儿童及青少年分化型甲状腺癌的基因特征与临床特征及 131 I疗效的关系 [J ] . 中国癌症杂志 , 2022 , 32 ( 5 ): 380 - 387 . DOI: 10.19401/j.cnki.1007-3639.2022.05.002 http://doi.org/10.19401/j.cnki.1007-3639.2022.05.002

SUN D , SUN Y Q , ZHANG X , et al . The relationship between genetic characteristics and clinical characteristics and the efficacy of 131 I therapy in children and adolescents with locally advanced or metastatic differentiated thyroid cancer [J ] . Chin Oncol , 2022 , 32 ( 5 ): 380 - 387 . DOI: 10.19401/j.cnki.1007-3639.2022.05.002 http://doi.org/10.19401/j.cnki.1007-3639.2022.05.002

NIES M , VASSILOPOULOU-SELLIN R , BASSETT R L , et al . Distant metastases from childhood differentiated thyroid carcinoma: clinical course and mutational landscape [J ] . J Clin Endocrinol Metab , 2021 , 106 ( 4 ): e1683 - e1697 . DOI: 10.1210/clinem/dgaa935 http://doi.org/10.1210/clinem/dgaa935

潘逸缙 , 鞠高达 , 慕转转 , 等 . 转移性儿童及青少年分化型甲状腺癌基因与临床特征的关系 [J ] . 中华医学杂志 , 2024 , 104 ( 20 ): 1837 - 1843 .

PAN Y J , JU G D , MU Z Z , et al . The relationship between differentially expressed thyroid cancer genes and clinical characteristics in metastatic children and adolescents [J ] . Natl Med J Chin , 2024 , 104 ( 20 ): 1837 - 1843 .

PAWELCZAK M , DAVID R , FRANKLIN B , et al . Outcomes of children and adolescents with well-differentiated thyroid carcinoma and pulmonary metastases following ¹³¹I treatment: a systematic review [J ] . Thyroid , 2010 , 20 ( 10 ): 1095 - 1101 . DOI: 10.1089/thy.2009.0446 http://doi.org/10.1089/thy.2009.0446

KIM K J , KIM K J , CHOI J , et al . Linear association between radioactive iodine dose and second primary malignancy risk in thyroid cancer [J ] . J Natl Cancer Inst , 2023 , 115 ( 6 ): 695 - 702 . DOI: 10.1093/jnci/djad040 http://doi.org/10.1093/jnci/djad040

VASSILOPOULOU-SELLIN R , GOEPFERT H , RANEY B , et al . Differentiated thyroid cancer in children and adolescents: clinical outcome and mortality after long-term follow-up [J ] . Head Neck , 1998 , 20 ( 6 ): 549 - 555 .

PASQUAL E , SCHONFELD S , MORTON L M , et al . Association between radioactive iodine treatment for pediatric and young adulthood differentiated thyroid cancer and risk of second primary malignancies [J ] . J Clin Oncol , 2022 , 40 ( 13 ): 1439 - 1449 . DOI: 10.1200/JCO.21.01841 http://doi.org/10.1200/JCO.21.01841

ZHAO X L , CHEN M J , QI X J , et al . Association of radioiodine for differentiated thyroid cancer and second breast cancer in female adolescent and young adult [J ] . Front Endocrinol , 2022 , 12 : 805194 .

浏览量

2456

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

基因突变特征与儿童及青少年分化型甲状腺癌远处转移相关性的meta分析

《2025版美国甲状腺学会成人分化型甲状腺癌管理指南》解读：分化型甲状腺癌的外照射放疗进展

《2025版美国甲状腺学会成人甲状腺结节管理指南》及《2025版美国甲状腺学会成人分化型甲状腺癌管理指南》解读：甲状腺结节及分化型甲状腺癌超声、CT、MRI以及消融部分的进展

《2025版美国甲状腺学会成人分化型甲状腺癌管理指南》解读：基因分型指导下甲状腺癌的精准诊疗模式

《2025版美国甲状腺学会成人分化型甲状腺癌管理指南》解读：围手术期甲状旁腺功能的评估、处理及术后TSH抑制的精准个体化管理

1993—2023年国际儿童及青少年分化型甲状腺癌131I治疗文献计量分析

Global trends of 131I-therapy for differentiated thyroid cancer in children and adolescents: a bibliometric analysis (1993-2003)

DOI：10.19401/j.cnki.1007-3639.2024.12.007

摘要

Abstract

关键词

Keywords

references

1993—2023年国际儿童及青少年分化型甲状腺癌¹³¹I治疗文献计量分析

Global trends of ¹³¹I-therapy for differentiated thyroid cancer in children and adolescents: a bibliometric analysis (1993-2003)