AKBARALI H I , MUCHHALA K H , JESSUP D K , et al . Chemotherapy induced gastrointestinal toxicities [J ] . Adv Cancer Res , 2022 , 155 : 131 - 166 . DOI: 10.1016/bs.acr.2022.02.007 http://doi.org/10.1016/bs.acr.2022.02.007

MCQUADE R M , STOJANOVSKA V , ABALO R , et al . Chemotherapy-induced constipation and diarrhea: pathophysiology, current and emerging treatments [J ] . Front Pharmacol , 2016 , 7 : 414 .

World Health Organization . Diarrhoeal disease . [EB/OL ] . [ 2024 - 10 - 15 ] https://www.who.int/en/news-room/fact-sheets/detail/diarrhoeal-disease https://www.who.int/en/news-room/fact-sheets/detail/diarrhoeal-disease https://www.who.int/en/news-room/fact-sheets/detail/diarrhoeal-disease .

National Cancer Institute . Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 [Z ] . 2017 .

FATA F , RON I G , KEMENY N , et al . 5-fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma [J ] . Cancer , 1999 , 86 ( 7 ): 1129 - 1134 .

IKUNO N , SODA H , WATANABE M , et al . Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum [J ] . J Natl Cancer Inst , 1995 , 87 ( 24 ): 1876 - 1883 .

STRINGER A M , GIBSON R J , LOGAN R M , et al . Faecal microflora and beta-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats [J ] . Cancer Biol Ther , 2008 , 7 ( 12 ): 1919 - 1925 .

PARNES H L , FUNG E , SCHIFFER C A . Chemotherapy-induced lactose intolerance in adults [J ] . Cancer , 1994 , 74 ( 5 ): 1629 - 1633 .

HOLMA R , LAATIKAINEN R , ORELL H , et al . Consumption of lactose, other FODMAPs and diarrhoea during adjuvant 5-fluorouracil chemotherapy for colorectal cancer [J ] . Nutrients , 2020 , 12 ( 2 ): 407 .

MCQUADE R M , STOJANOVSKA V , DONALD E L , et al . Irinotecan-induced gastrointestinal dysfunction is associated with enteric neuropathy, but increased numbers of cholinergic myenteric neurons [J ] . Front Physiol , 2017 , 8 : 391 . DOI: 10.3389/fphys.2017.00391 http://doi.org/10.3389/fphys.2017.00391

NYHLÉN A , LJUNGBERG B , NILSSON-EHLE I , et al . Impact of combinations of antineoplastic drugs on intestinal microflora in 9 patients with leukaemia [J ] . Scand J Infect Dis , 2002 , 34 ( 1 ): 17 - 21 .

CHIA D K A , SUNDAR R , KIM G , et al . Outcomes of a phase Ⅱ study of intraperitoneal paclitaxel plus systemic capecitabine and oxaliplatin (XELOX) for gastric cancer with peritoneal metastases [J ] . Ann Surg Oncol , 2023 , 30 ( 3 ): 1889 - 1890 .

VERA G , CASTILLO M , CABEZOS P A , et al . Enteric neuropathy evoked by repeated cisplatin in the rat [J ] . Neurogastroenterol Motil , 2011 , 23 ( 4 ): 370 - 378 , e162 - 3 .

WAFAI L , TAHER M , JOVANOVSKA V , et al . Effects of oxaliplatin on mouse myenteric neurons and colonic motility [J ] . Front Neurosci , 2013 , 7 : 30 .

GORSCHLÜTER M , MEY U , STREHL J , et al . Invasive fungal infections in neutropenic enterocolitis: a systematic analysis of pathogens, incidence, treatment and mortality in adult patients [J ] . BMC Infect Dis , 2006 , 6 : 35 .

MAROUN J A , ANTHONY L B , BLAIS N , et al . Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: a consensus statement by the Canadian Working Group on chemotherapy-induced diarrhea [J ] . Curr Oncol , 2007 , 14 ( 1 ): 13 - 20 . DOI: 10.3747/co.2007.96 http://doi.org/10.3747/co.2007.96

ARBUCKLE R B , HUBER S L , ZACKER C . The consequences of diarrhea occurring during chemotherapy for colorectal cancer: a retrospective study [J ] . Oncologist , 2000 , 5 ( 3 ): 250 - 259 .

ANDREYEV J , ROSS P , DONNELLAN C , et al . Guidance on the management of diarrhoea during cancer chemotherapy [J ] . Lancet Oncol , 2014 , 15 ( 10 ): e447 - 60 .

BOSSI P , ANTONUZZO A , CHERNY N I , et al . Diarrhoea in adult cancer patients: ESMO clinical practice guidelines [J ] . Ann Oncol , 2018 , 29 ( Suppl 4 ): iv126-iv142.

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES . Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 [EB/OL ] . [ 2024 - 10 - 15 ] . https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf https://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf .

BENSON A B 3rd , AJANI J A , CATALANO R B , et al . Recommended guidelines for the treatment of cancer treatment-induced diarrhea [J ] . J Clin Oncol , 2004 , 22 ( 14 ): 2918 - 2926 .

HUSAIN A , APTAKER L , SPRIGGS D R , et al . Gastrointestinal toxicity and Clostridium difficile diarrhea in patients treated with paclitaxel-containing chemotherapy regimens [J ] . Gynecol Oncol , 1998 , 71 ( 1 ): 104 - 107 . DOI: 10.1006/gyno.1998.5158 http://doi.org/10.1006/gyno.1998.5158

SOOD N , CARBELL G , GREENWALD H S , et al . Is the medium still the message? Culture-independent diagnosis of gastrointestinal infections [J ] . Dig Dis Sci , 2022 , 67 ( 1 ): 16 - 25 .

National comprehensive cancer network . NCCN clinical practice guidelines in oncology (NCCN Guidelines). Hematopoietic Growth Factors, version 1.2025 [EB/OL ] . [ 2024 - 10 - 15 ] . https://www.nccn.org/professionals/physician_gls/pdf/growthfactors.pdf https://www.nccn.org/professionals/physician_gls/pdf/growthfactors.pdf https://www.nccn.org/professionals/physician_gls/pdf/growthfactors.pdf .

CARTONI C , DRAGONI F , MICOZZI A , et al . Neutropenic enterocolitis in patients with acute leukemia: prognostic significance of bowel wall thickening detected by ultrasonography [J ] . J Clin Oncol , 2001 , 19 ( 3 ): 756 - 761 .

SCHNELL D , AZOULAY E , BENOIT D , et al . Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF) [J ] . Ann Intensive Care , 2016 , 6 ( 1 ): 90 . DOI: 10.1186/s13613-016-0189-6 http://doi.org/10.1186/s13613-016-0189-6

RUIZ-ARABI E , TORRE-CISNEROS J , AGUILERA V , et al . Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update [J ] . Transplant Rev (Orlando) , 2024 , 38 ( 4 ): 100875 .

MARASCO M , DELL’UNTO E , LAVIANO A , et al . Gastrointestinal side effects of somatostatin analogs in neuroendocrine tumors: a focused review [J ] . J Gastroenterol Hepatol , 2024 , 39 ( 9 ): 1737 - 1744 .

KUNE G A , KUNE S , FIELD B , et al . The role of chronic constipation, diarrhea, and laxative use in the etiology of large-bowel cancer. data from the Melbourne colorectal cancer study [J ] . Dis Colon Rectum , 1988 , 31 ( 7 ): 507 - 512 .

WOOD L D , CANTO M I , JAFFEE E M , et al . Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment [J ] . Gastroenterology , 2022 , 163 ( 2 ): 386 - 402 .e1 .

LI H , FU Z Y , ARSLAN M E , et al . Differential diagnosis and management of immune checkpoint inhibitor-induced colitis: a comprehensive review [J ] . World J Exp Med , 2021 , 11 ( 6 ): 79 - 92 . DOI: 10.5493/wjem.v11.i6.79 http://doi.org/10.5493/wjem.v11.i6.79

SUN K N , WANG X J , ZHANG H P , et al . Management and mechanisms of diarrhea induced by tyrosine kinase inhibitors in human epidermal growth factor receptor-2-positive breast cancer [J ] . Cancer Control , 2024 , 31 : 10732748241278039 .

LIU J N , YAN S , DU J T , et al . Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors [J ] . Heliyon , 2024 , 10 ( 6 ): e27531 .

DANIS R , MEGO M , ANTONOVA M , et al . Orally administered probiotics in the prevention of chemotherapy (± radiotherapy)-induced gastrointestinal toxicity: a systematic review with meta-analysis of randomized trials [J ] . Integr Cancer Ther , 2022 , 21 : 15347354221144309.

EFREMOVA I , MASLENNIKOV R , POLUEKTOVA E , et al . Epidemiology of small intestinal bacterial overgrowth [J ] . World J Gastroenterol , 2023 , 29 ( 22 ): 3400 - 3421 .

GEE C , FLEURET C , WILSON A , et al . Bile acid malabsorption as a consequence of cancer treatment: prevalence and management in the national leading centre [J ] . Cancers (Basel) , 2021 , 13 ( 24 ): 6213 .

XU Y S , XIONG L N , LI Y N , et al . Diagnostic methods and drug therapies in patients with ischemic colitis [J ] . Int J Colorectal Dis , 2021 , 36 ( 1 ): 47 - 56 .

SALVI F , PETRINO R , CONROY S P , et al . Constipation: a neglected condition in older emergency department patients [J ] . Intern Emerg Med , 2024 , 19 ( 7 ): 1977 - 1986 .

HANEDA R , HIRAMATSU Y , KAWATA S , et al . Clinical impact of diarrhea during enteral feeding after esophagectomy [J ] . Int J Clin Oncol , 2024 , 29 ( 1 ): 36 - 46 . DOI: 10.1007/s10147-023-02428-5 http://doi.org/10.1007/s10147-023-02428-5

PETRELLI N , HERRERA L , RUSTUM Y , et al . A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma [J ] . J Clin Oncol , 1987 , 5 ( 10 ): 1559 - 1565 . DOI: 10.1200/JCO.1987.5.10.1559 http://doi.org/10.1200/JCO.1987.5.10.1559

PETRELLI N , DOUGLASS H O Jr , HERRERA L , et al . The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase Ⅲ trial. Gastrointestinal tumor study group [J ] . J Clin Oncol , 1989 , 7 ( 10 ): 1419 - 1426 .

MEYERHARDT J A , MAYER R J . Systemic therapy for colorectal cancer [J ] . N Engl J Med , 2005 , 352 ( 5 ): 476 - 487 .

DEAN L , KANE M . Fluorouracil Therapy and DPYD Genotype [M ] //PRATT V M, SCOTT S A, PIRMOHAMED M, et al. Medical Genetics Summaries. Bethesda (MD). 2012 .

HAMAGUCHI T , SHIMADA Y , MIZUSAWA J , et al . Capecitabine versus S-1 as adjuvant chemotherapy for patients with stage Ⅲ colorectal cancer (JCOG0910): an open-label, non-inferiority, randomised, phase 3, multicentre trial [J ] . Lancet Gastroenterol Hepatol , 2018 , 3 ( 1 ): 47 - 56 .

SLOAN J A , GOLDBERG R M , SARGENT D J , et al . Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer [J ] . J Clin Oncol , 2002 , 20 ( 6 ): 1491 - 1498 . DOI: 10.1200/JCO.2002.20.6.1491 http://doi.org/10.1200/JCO.2002.20.6.1491

CASCINU S , BARNI S , LABIANCA R , et al . Evaluation of factors influencing 5-fluorouracil-induced diarrhea in colorectal cancer patients. An Italian Group for the study of digestive tract cancer (GISCAD) study [J ] . Support Care Cancer , 1997 , 5 ( 4 ): 314 - 317 .

INNOCENTI F . DPYD variants to predict 5-FU toxicity: the ultimate proof [J ] . J Natl Cancer Inst , 2014 , 106 ( 12 ): dju351.

MOREL A , BOISDRON-CELLE M , FEY L , et al . Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance [J ] . Mol Cancer Ther , 2006 , 5 ( 11 ): 2895 - 2904 . DOI: 10.1158/1535-7163.MCT-06-0327 http://doi.org/10.1158/1535-7163.MCT-06-0327

LEUNG H W C , CHAN A L F . Association and prediction of severe 5-fluorouracil toxicity with dihydropyrimidine dehydrogenase gene polymorphisms: a meta-analysis [J ] . Biomed Rep , 2015 , 3 ( 6 ): 879 - 883 .

HE Y F , WEI W , ZHANG X , et al . Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in Chinese cancer patients [J ] . J Clin Pharm Ther , 2008 , 33 ( 3 ): 307 - 314 . DOI: 10.1111/j.1365-2710.2008.00898.x http://doi.org/10.1111/j.1365-2710.2008.00898.x

李婷婷 , 谢颖 , 何林海 , 等 . 基于5-氟尿嘧啶的直肠癌化疗疗效和不良反应的相关基因多态性研究进展 [J ] . 肿瘤研究与临床 , 2019 , 31 ( 9 ): 644 - 648 .

LI T T , XIE Y , HE L H , et al . Progress of related gene polymorphism of 5-fluorouracil-based chemotherapy efficacy and adverse reactions in colorectal cancer [J ] . Cancer Res Clin , 2019 , 31 ( 9 ): 644 - 648 .

Clinical Pharmacogenetics Implementation Consortium . CPIC® Guideline for fluoropyrimidines and DPYD [EB/OL ] . https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/ https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/ https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/ .

KERR D J . Clinical efficacy of ‘Tomudex’ (raltitrexed) in advanced colorectal cancer [J ] . Anticancer Drugs , 1997 , 8 ( Suppl 2 ): S11 - S15 .

DIASIO R B , BEAVERS T L , CARPENTER J T . Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity [J ] . J Clin Invest , 1988 , 81 ( 1 ): 47 - 51 .

ABIGERGES D , CHABOT G G , ARMAND J P , et al . Phase Ⅰ and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients [J ] . J Clin Oncol , 1995 , 13 ( 1 ): 210 - 221 .

XU S K , LAN H Y , HUANG C Y , et al . Mechanisms and emerging strategies for irinotecan-induced diarrhea [J ] . Eur J Pharmacol , 2024 , 974 : 176614 .

SALIBA F , HAGIPANTELLI R , MISSET J L , et al . Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment [J ] . J Clin Oncol , 1998 , 16 ( 8 ): 2745 - 2751 .

FUCHS C S , MOORE M R , HARKER G , et al . Phase Ⅲ comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer [J ] . J Clin Oncol , 2003 , 21 ( 5 ): 807 - 814 .

HECHT J R . Gastrointestinal toxicity or irinotecan [J ] . Oncology (Williston Park) , 1998 , 12 (8 Suppl 6): 72 - 78 .

JIANG P C , WANG S W , LI C , et al . UGT1A1 genotype-guided irinotecan dosing during neoadjuvant chemoradiotherapy for locally advanced rectal cancer: a prospective analysis of SN-38 concentration [J ] . Int J Cancer , 2024 , 154 ( 8 ): 1484 - 1491 .

CHEN S J , HUA L , FENG C J , et al . Correlation between UGT1A1 gene polymorphism and irinotecan chemotherapy in metastatic colorectal cancer: a study from Guangxi Zhuang [J ] . BMC Gastroenterol , 2020 , 20 ( 1 ): 96 .

WANG Y , SHEN L , XU N , et al . UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil [J ] . World J Gastroenterol , 2012 , 18 ( 45 ): 6635 - 6644 .

WASSERMAN E , MYARA A , LOKIEC F , et al . Severe CPT-11 toxicity in patients with Gilbert’s syndrome: two case reports [J ] . Ann Oncol , 1997 , 8 ( 10 ): 1049 - 1051 .

ZHANG M , WANG H W , HUANG Y C , et al . Compound heterozygous UGT1A1 *28 and UGT1A1 *6 or single homozygous UGT1A1 *28 are major genotypes associated with Gilbert’s syndrome in Chinese Han people [J ] . Gene , 2021 , 781 : 145526 .

TAKEDA Y , KOBAYASHI K , AKIYAMA Y , et al . Prevention of irinotecan (CPT-11)-induced diarrhea by oral alkalization combined with control of defecation in cancer patients [J ] . Int J Cancer , 2001 , 92 ( 2 ): 269 - 275 .

CHAMSEDDINE A N , DUCREUX M , ARMAND J P , et al . Intestinal bacterial β-glucuronidase as a possible predictive biomarker of irinotecan-induced diarrhea severity [J ] . Pharmacol Ther , 2019 , 199 : 1 - 15 .

KWEEKEL D , GUCHELAAR H J , GELDERBLOM H . Clinical and pharmacogenetic factors associated with irinotecan toxicity [J ] . Cancer Treat Rev , 2008 , 34 ( 7 ): 656 - 669 . DOI: 10.1016/j.ctrv.2008.05.002 http://doi.org/10.1016/j.ctrv.2008.05.002

中国临床肿瘤学会 . 结直肠癌诊疗指南2024 [EB/OL ] . ( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] . https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf .

Chinese Society of Clinical Oncology . Guidelines for the diagnosis and treatment of colorectal cancer 2024 [EB/OL ] . ( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] . https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813105711.pdf .

ROTHENBERG M L , MEROPOL N J , POPLIN E A , et al . Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel [J ] . J Clin Oncol , 2001 , 19 ( 18 ): 3801 - 3807 . DOI: 10.1200/JCO.2001.19.18.3801 http://doi.org/10.1200/JCO.2001.19.18.3801

FUCHS C S , MARSHALL J , BARRUECO J . Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study [J ] . J Clin Oncol , 2008 , 26 ( 4 ): 689 - 690 . DOI: 10.1200/JCO.2007.15.5390 http://doi.org/10.1200/JCO.2007.15.5390

COLUCCI G , GEBBIA V , PAOLETTI G , et al . Phase Ⅲ randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell’Italia Meridionale [J ] . J Clin Oncol , 2005 , 23 ( 22 ): 4866 - 4875 .

XU R H , MURO K , MORITA S , et al . Modified XELIRI (capecitabine plus irinotecan) versus FOLFIRI (leucovorin, fluorouracil, and irinotecan), both either with or without bevacizumab, as second-line therapy for metastatic colorectal cancer (AXEPT): a multicentre, open-label, randomised, non-inferiority, phase 3 trial [J ] . Lancet Oncol , 2018 , 19 ( 5 ): 660 - 671 .

FALCONE A , RICCI S , BRUNETTI I , et al . Phase Ⅲ trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest [J ] . J Clin Oncol , 2007 , 25 ( 13 ): 1670 - 1676 .

中国临床肿瘤学会 . 胰腺癌诊疗指南2024 [EB/OL ] . ( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf .

Chinese Society of Clinical Oncology . Guidelines for the diagnosis and treatment of pancreatic cancer 2024 [EB/OL ] .( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf https://meeting.csco.org.cn/pdf/web/viewer.html?file=/Upload/Periodical/20240813112958.pdf .

CHANG T C , SHIAH H S , YANG C H , et al . Phase Ⅰ study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients [J ] . Cancer Chemother Pharmacol , 2015 , 75 ( 3 ): 579 - 586 .

ADIWIJAYA B S , KIM J , LANG I , et al . Population pharmacokinetics of liposomal irinotecan in patients with cancer [J ] . Clin Pharmacol Ther , 2017 , 102 ( 6 ): 997 - 1005 . DOI: 10.1002/cpt.720 http://doi.org/10.1002/cpt.720

WANG-GILLAM A , LI C P , BODOKY G , et al . Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial [J ] . Lancet , 2016 , 387 ( 10018 ): 545 - 557 .

BANG Y J , LI C P , LEE K H , et al . Liposomal irinotecan in metastatic pancreatic adenocarcinoma in Asian patients: Subgroup analysis of the NAPOLI-1 study [J ] . Cancer Sci , 2020 , 111 ( 2 ): 513 - 527 .

WAINBERG Z A , MELISI D , MACARULLA T , et al . NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial [J ] . Lancet , 2023 , 402 ( 10409 ): 1272 - 1281 . DOI: 10.1016/S0140-6736(23)01366-1 http://doi.org/10.1016/S0140-6736(23)01366-1

YOO C , KIM K P , JEONG J H , et al . Liposomal irinotecan plus fluorouracil and leucovorin versus fluorouracil and leucovorin for metastatic biliary tract cancer after progression on gemcitabine plus cisplatin (NIFTY): a multicentre, open-label, randomised, phase 2b study [J ] . Lancet Oncol , 2021 , 22 ( 11 ): 1560 - 1572 . DOI: 10.1016/S1470-2045(21)00486-1 http://doi.org/10.1016/S1470-2045(21)00486-1

BRENDEL K , BEKAII-SAAB T , BOLAND P M , et al . Population pharmacokinetics of liposomal irinotecan in patients with cancer and exposure-safety analyses in patients with metastatic pancreatic cancer [J ] . CPT Pharmacometrics Syst Pharmacol , 2021 , 10 ( 12 ): 1550 - 1563 .

ROY A C , PARK S R , CUNNINGHAM D , et al . A randomized phase Ⅱ study of PEP02 (MM-398), irinotecan or docetaxel as a second-line therapy in patients with locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma [J ] . Ann Oncol , 2013 , 24 ( 6 ): 1567 - 1573 .

CHIBAUDEL B , MAINDRAULT-GŒBEL F , BACHET J B , et al . PEPCOL: a GERCOR randomized phase Ⅱ study of nanoliposomal irinotecan PEP02 (MM-398) or irinotecan with leucovorin/5-fluorouracil as second-line therapy in metastatic colorectal cancer [J ] . Cancer Med , 2016 , 5 ( 4 ): 676 - 683 .

O’BRIEN B E , KAKLAMANI V G , BENSON A B 3rd . The assessment and management of cancer treatment-related diarrhea [J ] . Clin Colorectal Cancer , 2005 , 4 ( 6 ): 375-381; discussion 382-383.

EADALA P , WAUD J P , MATTHEWS S B , et al . Quantifying the ‘hidden’ lactose in drugs used for the treatment of gastrointestinal conditions [J ] . Aliment Pharmacol Ther , 2009 , 29 ( 6 ): 677 - 687 .

Stanford Cancer Nutrition Services . Diarrhea nutrition tips [EB/OL ] . ( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] . https://stanfordhealthcare.org/content/dam/SHC/programs-services/cancer-nutrition/docs/diarrhea-during-chemo-and-radiation-nutrition-facts.pdf https://stanfordhealthcare.org/content/dam/SHC/programs-services/cancer-nutrition/docs/diarrhea-during-chemo-and-radiation-nutrition-facts.pdf https://stanfordhealthcare.org/content/dam/SHC/programs-services/cancer-nutrition/docs/diarrhea-during-chemo-and-radiation-nutrition-facts.pdf .

DUGGAN C , FONTAINE O , PIERCE N F , et al . Scientific rationale for a change in the composition of oral rehydration solution [J ] . JAMA , 2004 , 291 ( 21 ): 2628 - 2631 .

RHODES A , EVANS L E , ALHAZZANI W , et al . Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 [J ] . Crit Care Med , 2017 , 45 ( 3 ): 486 - 552 . DOI: 10.1097/CCM.0000000000002255 http://doi.org/10.1097/CCM.0000000000002255

ZAMPIERI F G , BAGSHAW S M , SEMLER M W . Fluid therapy for critically ill adults with sepsis: a review [J ] . JAMA , 2023 , 329 ( 22 ): 1967 - 1980 . DOI: 10.1001/jama.2023.7560 http://doi.org/10.1001/jama.2023.7560

MUSCARITOLI M , ARENDS J , BACHMANN P , et al . ESPEN practical guideline: clinical nutrition in cancer [J ] . Clin Nutr , 2021 , 40 ( 5 ): 2898 - 2913 . DOI: 10.1016/j.clnu.2021.02.005 http://doi.org/10.1016/j.clnu.2021.02.005

OOMS L A , DEGRYSE A D , JANSSEN P A . Mechanisms of action of loperamide [J ] . Scand J Gastroenterol Suppl , 1984 , 96 : 145 - 155 .

CASCINU S , BICHISAO E , AMADORI D , et al . High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients [J ] . Support Care Cancer , 2000 , 8 ( 1 ): 65 - 67 .

EGGLESTON W , PALMER R , DUBÉ P A , et al . Loperamide toxicity: recommendations for patient monitoring and management [J ] . Clin Toxicol (Phila) , 2020 , 58 ( 5 ): 355 - 359 . DOI: 10.1080/15563650.2019.1681443 http://doi.org/10.1080/15563650.2019.1681443

LAMBERTS S W J , VAN DER LELY A J , DE HERDER W W , et al . Octreotide [J ] . N Engl J Med , 1996 , 334 ( 4 ): 246 - 254 .

DUENO M I , BAI J C , SANTANGELO W C , et al . Effect of somatostatin analog on water and electrolyte transport and transit time in human small bowel [J ] . Dig Dis Sci , 1987 , 32 ( 10 ): 1092 - 1096 .

MATON P N , O’DORISIO T M , HOWE B A , et al . Effect of a long-acting somatostatin analogue (SMS 201-995) in a patient with pancreatic cholera [J ] . N Engl J Med , 1985 , 312 ( 1 ): 17 - 21 .

PETRELLI N J , RODRIGUEZ-BIGAS M , RUSTUM Y , et al . Bowel rest, intravenous hydration, and continuous high-dose infusion of octreotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinoma [J ] . Cancer , 1993 , 72 ( 5 ): 1543 - 1546 .

WADLER S , HAYNES H , WIERNIK P H . Phase Ⅰ trial of the somatostatin analog octreotide acetate in the treatment of fluoropyrimidine-induced diarrhea [J ] . J Clin Oncol , 1995 , 13 ( 1 ): 222 - 226 .

ZIDAN J , HAIM N , BENY A , et al . Octreotide in the treatment of severe chemotherapy-induced diarrhea [J ] . Ann Oncol , 2001 , 12 ( 2 ): 227 - 229 .

BARBOUNIS V , KOUMAKIS G , VASSILOMANOLAKIS M , et al . Control of irinotecan-induced diarrhea by octreotide after loperamide failure [J ] . Support Care Cancer , 2001 , 9 ( 4 ): 258 - 260 .

GOUMAS P , NAXAKIS S , CHRISTOPOULOU A , et al . Octreotide acetate in the treatment of fluorouracil-induced diarrhea [J ] . Oncologist , 1998 , 3 ( 1 ): 50 - 53 .

CASCINU S , FEDELI A , FEDELI S L , et al . Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial [J ] . J Clin Oncol , 1993 , 11 ( 1 ): 148 - 151 .

GEBBIA V , CARRECA I , TESTA A , et al . Subcutaneous octreotide versus oral loperamide in the treatment of diarrhea following chemotherapy [J ] . Anticancer Drugs , 1993 , 4 ( 4 ): 443 - 445 .

CARDONA ZORRILLA A F , REVEIZ HERAULT L , CASASBUENAS A , et al . Systematic review of case reports concerning adults suffering from neutropenic enterocolitis [J ] . Clin Transl Oncol , 2006 , 8 ( 1 ): 31 - 38 . DOI: 10.1007/s12094-006-0092-y http://doi.org/10.1007/s12094-006-0092-y

LIN X L , FANG Y , CHENG Y , et al . Chinese herbal medicine for irinotecan-induced diarrhea: a systematic review and meta-analysis [J ] . Explore (NY) , 2024 , 20 ( 2 ): 158 - 167 .

WU Y H , WANG D , YANG X Q , et al . Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice [J ] . Biomed Pharmacother , 2019 , 109 : 2252 - 2261 . DOI: S0753-3322(18)36907-5 http://doi.org/S0753-3322(18)36907-5

李玉凤 , 张碧严 , 赖芸 , 等 . 半夏泻心汤对氟尿嘧啶致腹泻小鼠模型肠道免疫功能的影响 [J ] . 中国实验方剂学杂志 , 2014 , 20 ( 23 ): 180 - 184 .

LI Y F , ZHANG B Y , LAI Y , et al . Effects of Banxia Xiexin Tang on intestinal immune function in fluorouracil-induced diarrhea mice [J ] . Chin J Exp Tradit Med Formulae , 2014 , 20 ( 23 ): 180 - 184 .

TAKAHASHI T , NAGAI K , KOTAKE K . Efficacy of hangeshashinto in the prevention of chemotherapy-induced diarrhea: a systematic review and meta-analysis [J ] . Cureus , 2023 , 15 ( 12 ): e50377 .

ADAMS N , KUNENE V , MIKROPOULOS C . Management of systemic anti-cancer therapy induced diarrhoea in adult patients v2.3 [EB/OL ] . ( 2024 - 08 - 13 ) [ 2024 - 10 - 15 ] . https://www.england.nhs.uk/mids-east/wp-content/uploads/sites/7/2018/04/guidelines-for-management-of-diarrhoea-v2-3.pdf https://www.england.nhs.uk/mids-east/wp-content/uploads/sites/7/2018/04/guidelines-for-management-of-diarrhoea-v2-3.pdf https://www.england.nhs.uk/mids-east/wp-content/uploads/sites/7/2018/04/guidelines-for-management-of-diarrhoea-v2-3.pdf .

HOFF P M , SARAGIOTTO D F , BARRIOS C H , et al . Randomized phase Ⅲ trial exploring the use of long-acting release octreotide in the prevention of chemotherapy-induced diarrhea in patients with colorectal cancer: the LARCID trial [J ] . J Clin Oncol , 2014 , 32 ( 10 ): 1006 - 1011 .

VAN DEN HEUVEL B , PEETERS M , HENDLISZ A , et al . Long-acting octreotide as secondary prevention of chemotherapy-induced diarrhea: proof of concept [J ] . Minerva Chir , 2016 .

ASTRUC B , MARBACH P , BOUTERFA H , et al . Long-acting octreotide and prolonged-release lanreotide formulations have different pharmacokinetic profiles [J ] . J Clin Pharmacol , 2005 , 45 ( 7 ): 836 - 844 . DOI: 10.1177/0091270005277936 http://doi.org/10.1177/0091270005277936

OSTERLUND P , RUOTSALAINEN T , KORPELA R , et al . Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study [J ] . Br J Cancer , 2007 , 97 ( 8 ): 1028 - 1034 .

REDMAN M G , WARD E J , PHILLIPS R S . The efficacy and safety of probiotics in people with cancer: a systematic review [J ] . Ann Oncol , 2014 , 25 ( 10 ): 1919 - 1929 . DOI: S0923-7534(19)36598-6 http://doi.org/S0923-7534(19)36598-6