循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望

俞雪; 沈天皓; 周诚; 刘雨; 蒋霆辉; 李炜; 朱永强; 刘艳

doi:10.19401/j.cnki.1007-3639.2025.10.008

您当前的位置：

首页 >

文章列表页 >

循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望

综述 | 更新时间：2025-12-31

- 循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望
- Research progress and prospects on the mechanisms of circulating tumor cells in the invasion and metastasis of cholangiocarcinoma
- 中国癌症杂志 2025年35卷第10期页码：952-958
- 作者机构：
  
  1. 上海中医药大学附属普陀医院肿瘤介入科，上海 200062
  2. 上海中医药大学附属普陀医院肿瘤介入研究所，上海 200062
  3. 上海中医药大学附属普陀医院肝胆外科，上海 200062
- 作者简介：
  
  [ "俞雪（ORCID: 0009-0000-0918-8888），硕士研究生，上海中医药大学附属普陀医院介入科住院医师。" ]
  刘艳（ORCID：0000-0001-7205-1569），博士，上海中医药大学附属普陀医院介入科主治医师。
- 基金信息：
  
  上海市卫生健康委员会青年人才计划(2022YQ037);上海市普陀区卫生健康系统科技创新项目计划(ptkwws202210)
- DOI：10.19401/j.cnki.1007-3639.2025.10.008
  中图分类号： R735.8
- 收稿：2024-08-21，
  
  修回：2025-06-26，
  
  纸质出版：2025-10-30
- 稿件说明：
移动端阅览
俞雪, 沈天皓, 周诚, 等. 循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望[J]. 中国癌症杂志, 2025,35(10):952-958.

Xue YU, Tianhao SHEN, Cheng ZHOU, et al. Research progress and prospects on the mechanisms of circulating tumor cells in the invasion and metastasis of cholangiocarcinoma[J]. China Oncology, 2025, 35(10): 952-958.
俞雪, 沈天皓, 周诚, 等. 循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望[J]. 中国癌症杂志, 2025,35(10):952-958. DOI： 10.19401/j.cnki.1007-3639.2025.10.008.

Xue YU, Tianhao SHEN, Cheng ZHOU, et al. Research progress and prospects on the mechanisms of circulating tumor cells in the invasion and metastasis of cholangiocarcinoma[J]. China Oncology, 2025, 35(10): 952-958. DOI： 10.19401/j.cnki.1007-3639.2025.10.008.

摘要

胆管癌作为一种侵袭性强且预后较差的恶性肿瘤，其转移机制复杂，亟待深入研究。循环肿瘤细胞（circulating tumor cell，CTC）作为从原发部位脱落进入血液循环的关键肿瘤细胞类型，对肿瘤的转移具有重要的研究意义。近年来，研究发现，CTC的侵袭性伪足在肿瘤细胞迁移和侵袭中发挥了重要作用。其中，在信号转导通路方面的研究进展表现在：Rho家族GTP酶（RhoA、Rac1、Cdc42）分工协同调控伪足收缩力、肌动蛋白分支聚合及导向，磷脂酰肌醇3-激酶（phosphoinositide3-kinase，PI3K）/蛋白激酶B（protein kinase B，AKT）信号转导通路通过激活AKT促进肌动蛋白组装并与Rho家族交叉对话；在分子机制上的研究进展包括：长链非编码RNA通过吸附miRNA等方式调控伪足相关基因表达，基质金属蛋白酶（matrix metalloproteinase，MMP）降解细胞外基质（extracellular matrix，ECM）形成侵袭正反馈；在微环境方面的研究进展包括：癌相关成纤维细胞（cancer-associated fibroblast，CAF）和巨噬细胞分泌的转化生长因子-β（transforming growth factor-beta，TGF-β）、表皮生长因子（epidermal growth factor，EGF）、白细胞介素-6（interleukin-6，IL-6）等细胞因子激活伪足形成信号转导通路，ECM硬度与纤维排列通过机械力传导影响伪足伸展。本文通过对CTC的生物学特性、胆管癌细胞侵袭性伪足的形成机制、胆管癌细胞的转移特征及其临床意义、CTC在胆管癌转移过程中的作用进行综合分析，总结现有研究成果并探讨潜在的治疗靶点，为胆管癌防治研究工作者提供参考。

Abstract

Cholangiocarcinoma

as a malignant tumor with strong invasiveness and poor prognosis

has a complex metastasis mechanism

and urgently needs in-depth research. Circulating tumor cells (CTC)

as the key cell type for tumor cells to shed from the primary site and enter the bloodstream

have significant research significance. In recent years

studies have found that the invasive pseudopodia of CTC play a significant role in the migration and invasion of tumor cells. Among them

in terms of signal transduction pathways

the Rho family GTPases (RhoA

Rac1

Cdc42) work in coordination to regulate the contractility of the pseudofoot

the branching polymerization and orientation of actin

and the phosphoinositide3-kinase/protein kinase B (PI3K/AKT) pathway promotes the assembly of actin and cross-communicates with the Rho family by activating AKT. At the molecular mechanism level

long non-coding RNAs regulate the expression of pseudopolypod-related genes by adsorbing miRNAs and other means. Matrix metalloproteinase (MMP) degrades the extracellular matrix (ECM) to form an invasion positive feedback. In terms of the microenvironment

cancer-associated fibroblast (CAF) and the cytokines such as transforming growth factor-β (TGF-β) secreted by macrophages

epidermal growth factor (EGF)

and interleukin-6 (IL-6) activate pseudopodia to form signal transduction pathways. ECM hardness and fiber arrangement affect the extension direction of pseudopodia through mechanical force conduction. This article conducted a comprehensive analysis of the biological characteristics of CTC

the formation mechanism of invasive pseudopodia in cholangiocarcinoma

the metastatic features of cholangiocarcinoma cells and their clinical significance

as well as the role of CTC in the metastatic process of cholangiocarcinoma

in order to summarize the existing research results

explore potential therapeutic targets and future research directions

and provide new ideas for the clinical treatment of cholangiocarcinoma.

关键词

Keywords

references

ZHANG Y W , GVOZDENOVIC A , ACETO N . A molecular voyage: multiomics insights into circulating tumor cells [J ] . Cancer Discov , 2024 , 14 ( 6 ): 920 - 933 . DOI: 10.1158/2159-8290.CD-24-0218 http://doi.org/10.1158/2159-8290.CD-24-0218 https://aacrjournals.org/cancerdiscovery/article/14/6/920/745530/A-Molecular-Voyage-Multiomics-Insights-into https://aacrjournals.org/cancerdiscovery/article/14/6/920/745530/A-Molecular-Voyage-Multiomics-Insights-into

GURZU S , SZODORAI R , JUNG I , et al . Combined hepatocellular-cholangiocarcinoma: from genesis to molecular pathways and therapeutic strategies [J ] . J Cancer Res Clin Oncol , 2024 , 150 ( 5 ): 270 . DOI: 10.1007/s00432-024-05781-8 http://doi.org/10.1007/s00432-024-05781-8

SUN Y F , LI T , DING L , et al . Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT [J ] . Hepatology , 2025 , 81 ( 3 ): 791 - 807 . DOI: 10.1097/HEP.0000000000000934 http://doi.org/10.1097/HEP.0000000000000934 https://journals.lww.com/10.1097/HEP.0000000000000934 https://journals.lww.com/10.1097/HEP.0000000000000934

FABISIEWICZ A , SZOSTAKOWSKA-RODZOS M , ZACZEK A J , et al . Circulating tumor cells in early and advanced breast cancer; biology and prognostic value [J ] . Int J Mol Sci , 2020 , 21 ( 5 ): 1671 . DOI: 10.3390/ijms21051671 http://doi.org/10.3390/ijms21051671 https://www.mdpi.com/1422-0067/21/5/1671 https://www.mdpi.com/1422-0067/21/5/1671

ARNOLD L , YAP M , FARROKHIAN N , et al . DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma [J ] . Mol Cancer , 2025 , 24 ( 1 ): 50 . DOI: 10.1186/s12943-025-02264-3 http://doi.org/10.1186/s12943-025-02264-3

HAO Z X , ZHANG M R , DU Y , et al . Invadopodia in cancer metastasis: dynamics, regulation, and targeted therapies [J ] . J Transl Med , 2025 , 23 ( 1 ): 548 . DOI: 10.1186/s12967-025-06526-y http://doi.org/10.1186/s12967-025-06526-y

HSU C M , LIU Y C , HUANG J F . Exploring circulating tumor cells: detection methods and biomarkers for clinical evaluation in hepatocellular carcinoma [J ] . J Clin Transl Hepatol , 2024 , 12 ( 12 ): 1020 - 1042 .

PEI F , TAO Z , LU Q , et al . Octamer-binding transcription factor 4-positive circulating tumor cell predicts worse treatment response and survival in advanced cholangiocarcinoma patients who receive immune checkpoint inhibitors treatment [J ] . World J Surg Oncol , 2024 , 22 ( 1 ): 110 . DOI: 10.1186/s12957-024-03369-7 http://doi.org/10.1186/s12957-024-03369-7

YANG J D , CAMPION M B , LIU M C , et al . Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma [J ] . Hepatology , 2016 , 63 ( 1 ): 148 - 58 . DOI: 10.1002/hep.27944 http://doi.org/10.1002/hep.27944

ROSSI T , VALGIUSTI M , PUCCETTI M , et al . Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation [J ] . Cell Death Dis , 2025 , 16 ( 1 ): 223 . DOI: 10.1038/s41419-025-07530-2 http://doi.org/10.1038/s41419-025-07530-2

HAO W D , DONG X C , WANG Z J , et al . CRABP2 promotes peritoneal metastasis in CRC through TGF-β/Smad-mediated EMT signaling and invadopodia formation [J ] . Cell Signal , 2025 , 134 : 111927 . DOI: 10.1016/j.cellsig.2025.111927 http://doi.org/10.1016/j.cellsig.2025.111927 https://linkinghub.elsevier.com/retrieve/pii/S0898656825003420 https://linkinghub.elsevier.com/retrieve/pii/S0898656825003420

ALLGAYER H , MAHAPATRA S , MISHRA B , et al . Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 [J ] . Mol Cancer , 2025 , 24 ( 1 ): 167 . DOI: 10.1186/s12943-025-02338-2 http://doi.org/10.1186/s12943-025-02338-2

LI C , HE W , WANG N , et al . Application of microfluidics in detection of circulating tumor cells [J ] . Front Bioeng Biotechnol , 2022 , 10 : 907232 . DOI: 10.3389/fbioe.2022.907232 http://doi.org/10.3389/fbioe.2022.907232 https://www.frontiersin.org/articles/10.3389/fbioe.2022.907232/full https://www.frontiersin.org/articles/10.3389/fbioe.2022.907232/full

HASSANZADEH-BARFOROUSHI A , TUKOVA A , NADALINI A , et al . Microfluidic-SERS technologies for CTC: a perspective on clinical translation [J ] . ACS Appl Mater Interfaces , 2024 , 16 ( 18 ): 22761 - 22775 .

GOSTOMCZYK K , MARSOOL M D M , TAYYAB H , et al . Targeting circulating tumor cells to prevent metastases [J ] . Hum Cell , 2024 , 37 ( 1 ): 101 - 120 . DOI: 10.1007/s13577-023-00992-6 http://doi.org/10.1007/s13577-023-00992-6

ZHOU X , KONG X H , LU J , et al . Circulating tumor cell-derived exosome-transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells [J ] . J Nanobiotechnology , 2024 , 22 ( 1 ): 191 . DOI: 10.1186/s12951-024-02459-8 http://doi.org/10.1186/s12951-024-02459-8

ZHANG Q , KONG D F , YANG Z R , et al . Prognostic value of stem-like circulating tumor cells in patients with cancer: a systematic review and meta-analysis [J ] . Clin Exp Med , 2023 , 23 ( 6 ): 1933 - 1944 . DOI : 10.1007/s10238-023-01009-0 http://doi.org/10.1007/s10238-023-01009-0

TRETYAKOVA M S , MENYAILO M E , SCHEGOLEVA A A , et al . Technologies for viable circulating tumor cell isolation [J ] . Int J Mol Sci , 2022 , 23 ( 24 ): 15979 . DOI: 10.3390/ijms232415979 http://doi.org/10.3390/ijms232415979 https://www.mdpi.com/1422-0067/23/24/15979 https://www.mdpi.com/1422-0067/23/24/15979

TANG R , LUO S J , LIU H , et al . Circulating tumor microenvironment in metastasis [J ] . Cancer Res , 2025 , 85 ( 8 ): 1354 - 1367 .

KROG B L , HENRY M D . Biomechanics of the circulating tumor cell microenvironment [J ] . Adv Exp Med Biol , 2018 , 1092 : 209 - 233 . DOI: 10.1007/978-3-319-95294-9_11 http://doi.org/10.1007/978-3-319-95294-9_11

NAGAOKA K , OGAWA K , JI C C , et al . Targeting aspartate beta-hydroxylase with the small molecule inhibitor MO-I-1182 suppresses cholangiocarcinoma metastasis [J ] . Dig Dis Sci , 2021 , 66 ( 4 ): 1080 - 1089 . DOI: 10.1007/s10620-020-06330-2 http://doi.org/10.1007/s10620-020-06330-2

LAWRENCE R , WATTERS M , DAVIES C R , et al . Circulating tumour cells for early detection of clinically relevant cancer [J ] . Nat Rev Clin Oncol , 2023 , 20 ( 7 ): 487 - 500 . DOI: 10.1038/s41571-023-00781-y http://doi.org/10.1038/s41571-023-00781-y

WU Q Y , GU Z R , SHANG B Q , et al . Circulating tumor cell clustering modulates RNA splicing and polyadenylation to facilitate metastasis [J ] . Cancer Lett , 2024 , 588 : 216757 . DOI: 10.1016/j.canlet.2024.216757 http://doi.org/10.1016/j.canlet.2024.216757 https://linkinghub.elsevier.com/retrieve/pii/S0304383524001502 https://linkinghub.elsevier.com/retrieve/pii/S0304383524001502

XU D M , ZHUANG X Y , MA H L , et al . Altered tumor microenvironment heterogeneity of penile cancer during progression from non-lymphatic to lymphatic metastasis [J ] . Cancer Med , 2024 , 13 ( 14 ): e70025 . DOI: 10.1002/cam4.v13.14 http://doi.org/10.1002/cam4.v13.14 https://onlinelibrary.wiley.com/toc/20457634/13/14 https://onlinelibrary.wiley.com/toc/20457634/13/14

XU D M , CHEN L X , ZHUANG X Y , et al . The role of JAK-STAT-SOCS1 axis in tumorigenesis, malignant progression and lymphatic metastasis of penile cancer [J ] . Int J Med Sci , 2024 , 21 ( 6 ): 1176 - 1186 . DOI: 10.7150/ijms.95490 http://doi.org/10.7150/ijms.95490 https://www.medsci.org/v21p1176.htm https://www.medsci.org/v21p1176.htm

GUO S Y , HUANG J , LI G P , et al . The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis [J ] . Mol Cancer , 2023 , 22 ( 1 ): 193 . DOI: 10.1186/s12943-023-01909-5 http://doi.org/10.1186/s12943-023-01909-5

KISS I , KOLOSTOVA K , PAWLAK I , et al . Circulating tumor cells in gynaecological malignancies [J ] . J BUON , 2020 , 25 ( 1 ): 40 - 50 .

SUVILESH K N , MANJUNATH Y , PANTEL K , et al . Preclinical models to study patient-derived circulating tumor cells and metastasis [J ] . Trends Cancer , 2023 , 9 ( 4 ): 355 - 371 . DOI: 10.1016/j.trecan.2023.01.004 http://doi.org/10.1016/j.trecan.2023.01.004

TOCCI P , CAPRARA V , ROMAN C , et al . YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer [J ] . Biosci Rep , 2024 , 44 ( 12 ): BSR20241320 . DOI: 10.1042/BSR20241320 http://doi.org/10.1042/BSR20241320 https://portlandpress.com/bioscirep/article/44/12/BSR20241320/235208/YAP-signaling-orchestrates-the-endothelin-1-guided https://portlandpress.com/bioscirep/article/44/12/BSR20241320/235208/YAP-signaling-orchestrates-the-endothelin-1-guided

DAVIS S S , BASSARO L R , TUMA P L . MAL2 and rab17 selectively redistribute invadopodia proteins to laterally-induced protrusions in hepatocellular carcinoma cells [J ] . Mol Biol Cell , 2025 , 36 ( 3 ): ar26 . DOI: 10.1091/mbc.E24-09-0400 http://doi.org/10.1091/mbc.E24-09-0400 https://www.molbiolcell.org/doi/10.1091/mbc.E24-09-0400 https://www.molbiolcell.org/doi/10.1091/mbc.E24-09-0400

TANG Y Y , HE Y , ZHANG P , et al . LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis [J ] . Mol Cancer , 2018 , 17 ( 1 ): 77 . DOI: 10.1186/s12943-018-0825-x http://doi.org/10.1186/s12943-018-0825-x

DOLSKII A , ALCANTARA DOS SANTOS S A , ANDRAKE M , et al . Exploring the potential role of palladin in modulating human CAF/ECM functional units [J ] . Cytoskeleton , 2025 , 82 ( 3 ): 175 - 185 . DOI: 10.1002/cm.v82.3 http://doi.org/10.1002/cm.v82.3 https://onlinelibrary.wiley.com/toc/19493592/82/3 https://onlinelibrary.wiley.com/toc/19493592/82/3

XIN X , CHENG X Y , ZENG F X , et al . The role of TGF-β/SMAD signaling in hepatocellular carcinoma: From mechanism to therapy and prognosis [J ] . Int J Biol Sci , 2024 , 20 ( 4 ): 1436 - 1451 . DOI: 10.7150/ijbs.89568 http://doi.org/10.7150/ijbs.89568

MAHAKI H , NOBARI S , TANZADEHPANAH H , et al . Targeting VEGF signaling for tumor microenvironment remodeling and metastasis inhibition: therapeutic strategies and insights [J ] . Biomed Pharmacother , 2025 , 186 : 118023 . DOI: 10.1016/j.biopha.2025.118023 http://doi.org/10.1016/j.biopha.2025.118023 https://linkinghub.elsevier.com/retrieve/pii/S0753332225002173 https://linkinghub.elsevier.com/retrieve/pii/S0753332225002173

BRAVO-CORDERO J J , HODGSON L , CONDEELIS J S . Spatial regulation of tumor cell protrusions by RhoC [J ] . Cell Adh Migr , 2014 , 8 ( 3 ): 263 - 267 . DOI: 10.4161/cam.28405 http://doi.org/10.4161/cam.28405 http://www.tandfonline.com/doi/abs/10.4161/cam.28405 http://www.tandfonline.com/doi/abs/10.4161/cam.28405

KIM K H , YI H S , LEE H , et al . Targeting the sequences of circulating tumor DNA of cholangiocarcinomas and its applications and limitations in clinical practice [J ] . Int J Mol Sci , 2023 , 24 ( 8 ): 7512 . DOI: 10.3390/ijms24087512 http://doi.org/10.3390/ijms24087512 https://www.mdpi.com/1422-0067/24/8/7512 https://www.mdpi.com/1422-0067/24/8/7512

SHARIFI M N , SPERGER J M , TAYLOR A K , et al . High-purity CTC RNA sequencing identifies prostate cancer lineage phenotypes prognostic for clinical outcomes [J ] . Cancer Discov , 2025 , 15 ( 5 ): 969 - 987 . DOI: 10.1158/2159-8290.CD-24-1509 http://doi.org/10.1158/2159-8290.CD-24-1509 https://aacrjournals.org/cancerdiscovery/article/15/5/969/761993/High-Purity-CTC-RNA-Sequencing-Identifies-Prostate https://aacrjournals.org/cancerdiscovery/article/15/5/969/761993/High-Purity-CTC-RNA-Sequencing-Identifies-Prostate

DUTTA D , AL HOQUE A , PAUL B , et al . EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment [J ] . J Biomed Sci , 2024 , 31 ( 1 ): 81 . DOI: 10.1186/s12929-024-01069-8 http://doi.org/10.1186/s12929-024-01069-8

XUE W H , YANG L , CHEN C X , et al . Wnt/β-catenin-driven EMT regulation in human cancers [J ] . Cell Mol Life Sci , 2024 , 81 ( 1 ): 79 . DOI: 10.1007/s00018-023-05099-7 http://doi.org/10.1007/s00018-023-05099-7

ALEMZADEH E , ALLAHQOLI L , DEHGHAN H , et al . Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring [J ] . Oncol Res , 2023 , 31 ( 5 ): 667 - 675 . DOI: 10.32604/or.2023.028406 http://doi.org/10.32604/or.2023.028406

NING Y D , ZHENG M Y , ZHANG Y , et al . RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential [J ] . Cancer Cell Int , 2024 , 24 ( 1 ): 339 . DOI: 10.1186/s12935-024-03519-7 http://doi.org/10.1186/s12935-024-03519-7

ZHU B B , CAO A Y , CHEN C Q , et al . MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity [J ] . Int Immunopharmacol , 2024 , 126 : 111215 . DOI: 10.1016/j.intimp.2023.111215 http://doi.org/10.1016/j.intimp.2023.111215 https://linkinghub.elsevier.com/retrieve/pii/S1567576923015424 https://linkinghub.elsevier.com/retrieve/pii/S1567576923015424

RAPANOTTI M C , CENCI T , SCIOLI M G , et al . Circulating tumor cells: Origin, role, current applications, and future perspectives for personalized medicine [J ] . Biomedicines , 2024 , 12 ( 9 ): 2137 . DOI: 10.3390/biomedicines12092137 http://doi.org/10.3390/biomedicines12092137 https://www.mdpi.com/2227-9059/12/9/2137 https://www.mdpi.com/2227-9059/12/9/2137

DONATO C , KUNZ L , CASTRO-GINER F , et al . Hypoxia triggers the intravasation of clustered circulating tumor cells [J ] . Cell Rep , 2020 , 32 ( 10 ): 108105 . DOI: 10.1016/j.celrep.2020.108105 http://doi.org/10.1016/j.celrep.2020.108105 https://linkinghub.elsevier.com/retrieve/pii/S2211124720310949 https://linkinghub.elsevier.com/retrieve/pii/S2211124720310949

SOMSEN B A , COSSAR P J , ARKIN M R , et al . 14-3-3 protein-protein interactions: From mechanistic understanding to their small-molecule stabilization [J ] . Chembiochem , 2024 , 25 ( 14 ): e202400214 . DOI: 10.1002/cbic.v25.14 http://doi.org/10.1002/cbic.v25.14 https://chemistry-europe.onlinelibrary.wiley.com/toc/14397633/25/14 https://chemistry-europe.onlinelibrary.wiley.com/toc/14397633/25/14

HUANG L , WANG J X , WANG X Y , et al . Sulforaphane suppresses bladder cancer metastasis via blocking actin nucleation-mediated pseudopodia formation [J ] . Cancer Lett , 2024 , 601 : 217145 . DOI: 10.1016/j.canlet.2024.217145 http://doi.org/10.1016/j.canlet.2024.217145 https://linkinghub.elsevier.com/retrieve/pii/S0304383524005408 https://linkinghub.elsevier.com/retrieve/pii/S0304383524005408

ZHOU Y , CAO Y D , LIU W D , et al . Leveraging a gene signature associated with disulfidptosis identified by machine learning to forecast clinical outcomes, immunological heterogeneities, and potential therapeutic targets within lower-grade glioma [J ] . Front Immunol , 2023 , 14 : 1294459 . DOI: 10.3389/fimmu.2023.1294459 http://doi.org/10.3389/fimmu.2023.1294459 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294459/full https://www.frontiersin.org/articles/10.3389/fimmu.2023.1294459/full

WANG X , ZHANG H Y , CHEN X Z . Drug resistance and combating drug resistance in cancer [J ] . Cancer Drug Resist , 2019 , 2 ( 2 ): 141 - 160 .

ZHANG Q , ZHANG X L , LV Z H , et al . Dynamically monitoring minimal residual disease using circulating tumor cells to predict the recurrence of early-stage lung adenocarcinoma [J ] . J Hematol Oncol , 2024 , 17 ( 1 ): 114 . DOI: 10.1186/s13045-024-01637-3 http://doi.org/10.1186/s13045-024-01637-3

MENG S , SØRENSEN E E , PONNIAH M , et al . MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells [J ] . J Cell Sci , 2024 , 137 ( 8 ): jcs261608 . DOI: 10.1242/jcs.261608 http://doi.org/10.1242/jcs.261608 https://journals.biologists.com/jcs/article/137/8/jcs261608/347063/MCT4-and-CD147-colocalize-with-MMP14-in https://journals.biologists.com/jcs/article/137/8/jcs261608/347063/MCT4-and-CD147-colocalize-with-MMP14-in

QUILAQUEO-MILLAQUEO N , BROWN-BROWN D A , VIDAL-VIDAL J A , et al . NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion [J ] . Biol Res , 2024 , 57 ( 1 ): 98 . DOI: 10.1186/s40659-024-00577-z http://doi.org/10.1186/s40659-024-00577-z

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

MYC通过靶向CD47促进前列腺癌增殖和转移的机制研究

87例唾液腺导管癌患者的治疗策略与预后分析：一项回顾性队列研究

没食子酸增强CAR-T细胞抗实体瘤作用的研究

卡瑞利珠单抗联合化疗及靶向治疗在复发、转移及初治晚期宫颈癌中的疗效与安全性分析：一项回顾性队列研究

Circ-0007766作为miR-1972海绵调控HER2表达促进乳腺癌细胞迁移和侵袭