Ⅲ<sub>A</sub>(N<sub>2</sub>)期非小细胞肺癌术后放疗疗效分析

刘翼; 阿迪力; 陆艳荣; 张国庆; 庞作良

doi:10.3969/j.issn.1007-3969.2013.06.009

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Ⅲ_A(N₂)期非小细胞肺癌术后放疗疗效分析

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- Ⅲ_A(N₂)期非小细胞肺癌术后放疗疗效分析
- Analyze the curative effect of adjuwant radiotherapy in stage Ⅲ_A(N₂) non-small cell lung cancer
- 中国癌症杂志 2013年23卷第6期页码：452-456
- 作者机构：
  
  新疆医科大学附属肿瘤医院胸外科,新疆,乌鲁木齐
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.06.009
  中图分类号：
- 网络出版：2014-11-13，
  
  纸质出版：2013
- 稿件说明：
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刘翼,阿迪力,陆艳荣,张国庆,庞作良. Ⅲ

刘翼, 阿迪力, 陆艳荣, et al. Analyze the curative effect of adjuwant radiotherapy in stage Ⅲ_A(N₂) non-small cell lung cancer[J]. China Oncology, 2013, 23(6): 452-456.
刘翼,阿迪力,陆艳荣,张国庆,庞作良. Ⅲ DOI： 10.3969/j.issn.1007-3969.2013.06.009.

刘翼, 阿迪力, 陆艳荣, et al. Analyze the curative effect of adjuwant radiotherapy in stage Ⅲ_A(N₂) non-small cell lung cancer[J]. China Oncology, 2013, 23(6): 452-456. DOI： 10.3969/j.issn.1007-3969.2013.06.009.

摘要

背景与目的：术后放射治疗(postoperative radiotherapy，PORT)在完全性切除的Ⅲ

)期非小细胞肺癌(non-small cell lung cancer，NSCLC)治疗中的临床价值存在争议。本研究分析PORT在完全性切除的Ⅲ

)期NSCLC的疗效。方法：回顾性分析2002年1月—2007年1月126例在我院接受手术治疗的Ⅲ

)期NSCLC患者的临床资料。根据是否行术后放疗分为术后化疗组(n=56)和术后放化疗组(n=70)，分析Ⅲ

)期NSCLC生存期的影响因素。统计分析采用Kaplan-Meier法计算生存率，采用Log-rank比较各组生存的差异。结果：全组患者中位生存期25.0个月，1、3、5年生存率分别为84.4%、32.5%、16.4%。术后化疗组1、3、5年生存率分别为81.2%、28.5%、13.5%，中位生存期为22.4个月，术后化疗联合放疗组1、3、5年生存率分别为88.5%、39.9%、20.0%，中位生存期32.8个月，差异有统计学意义(P=0.033)。术后化疗组出现局部复发的中位时间为9.6个月，术后化疗联合放疗组出现局部复发的中位时间为17.0个月，差异有统计学意义(P=0.001)。单因素分析发现，多站淋巴结转移(P=0.001)、PORT(P=0.033)影响Ⅲ

)期NSCLC的生存率。结论：术后辅助放疗可提高pN2期NSCLC的生存率和降低局部复发。

Abstract

Background and purpose: Postoperative radiotherapy (PORT) in completely resectable stage Ⅲ

) non-small cell lung cancer (NSCLC) is still controversial. The purpose of this study was to analyze the efficiency of PORT in completely resectable stage Ⅲ

) NSCLC. Methods: The clinical data of 126 patients with stage Ⅲ

) NSCLC who was treated with radical surgery f

rom Jan. 2002 to Jan. 2007 were retrospctively analyzed. There were 126 patients for analysis; 70 patients received the postoperative chemotherapy alone (non-PORT)

56 patients received postoperative chemotherapy with radiotherapy. The 126 patients were analyzed the influencing factors of the overall survival (OS). Kaplan-Meier method was used to calculate the OS

and Log-rank was used to compare the difference of OS between the two groups. Results: The median survival time was 25.0 months in all the groups of patients. The 1-

5-year survival rates were 84.4%

32.5%

16.4%. The 1-

and 5-year survival rates were 81.2%

28.5%

13.5% in non-PORT group

and 88.5%

39.9%

20.0% in PORT group. The median survival time was 22.4 months and 32.8 months

the difference was statistically significant (P=0.033). The median time of stage Ⅲ

) NSCLC with locoregional recurrence was 9.6 months in non-PORT group and 17.0 months in PORT group

the difference was statistically significant (P=0.001). Univariate analysis showed that the number of lymph node metastasis station (P=0.001) and PORT (P=0.033) correlated with OS. Conclusion: PORT could improve the survival rate and reduce the locoregional recurrence of stage Ⅲ

) NSCLC.

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ⅢA(N2)期非小细胞肺癌术后放疗疗效分析

Analyze the curative effect of adjuwant radiotherapy in stage ⅢA(N2) non-small cell lung cancer

DOI：10.3969/j.issn.1007-3969.2013.06.009

摘要

Abstract

关键词

Keywords

references

Ⅲ_A(N₂)期非小细胞肺癌术后放疗疗效分析

Analyze the curative effect of adjuwant radiotherapy in stage Ⅲ_A(N₂) non-small cell lung cancer