Deubiquitinating enzymes

reversing protein ubiquitination

most of the researches focused on the field of molecular biology. However

it have not yet attracted enough attention in translational medicine research. In fact

target proteins of deubiquitinating enzymes affect the tumor progression through various ways

for example

cell apoptosis and autophagy

the link between inflammation and cancer

tumor hypoxia

signal transduction

cell cycle regulation and DNA damage. This paper reviewed the research progress on the relations between deubiquitinating enzymes and the correlated factors of tumor.