This paper is about the clinical trials of preoperative concurrent chemoradiotherapy for advanced adenocarcinoma of the stomach or gastroesophageal junction reported in recent years. The radiation dose of most trials is 45 Gy. Chemotherapy drugs such as 5-fluorouracil

cisplatin and taxol are concurrently used as sensitizers. A number of trials have induction chemotherapy prior to chemoradiotherpy. The validity is evaluated by R0 resection rate

pathological complete response rate and overall survival rate. The safety is assessed by the adverse reaction

treatment related mortality

and its effect on postoperative complications and mortality. The results showed that preoperative chemoradiotherapy can significantly improve the R0 resection rate and benefit the prognosis of the patients. Meanwhile

the security and impact on operations of preoperative chemoradiotherapy is controllable. The recent researches are mostly in phase II

and more randomized controlled studies are needed. To fully accept the preoperative chemoradiotherapy as a standard treatment

more evidence and long-term efficacy index are indispensible.