刘杨, 杨恭, 臧荣余. The mechanism of Notch3 mediated progression of ovarian cancer[J]. China Oncology, 2013, 23(12): 1001-1006. DOI: 10.3969/j.issn.1007-3969.2013.12.012.
Notch signal pathway is one of crucial pathways related to cell fate determination
regulating cell differentiation
proliferation and apoptosis
with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells
such as brain tumors
breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ovarian cancer has been attracted extensive attention by experts and scholars.This review focuses on the literatures of Notch3 and related molecules regulating the development and progression of epithelial ovarian cancer.