Background and purpose: Papillary renal cell carcinomas (PRCC) is relatively infrequent

and there are few related researches in China. This study aimed to summarize the clinical and pathological features of PRCC

and evaluate prognostic factors for patients treated with surgery. Methods: A total of 64 patients who underwent surgery for PRCC were retrospectively assessed. PRCC tissue slides from each patient were reviewed for type (Ⅰor Ⅱ)

grade

TNM stage

coagulative tumor necrosis and microvascular invasion. We estimated overall survival using the Kaplan-Meier method. Multivariate analysis was done according to the Cox proportional hazards model of factors statistically significant on univariate analysis. Results: The incidence rate of ENE was 6.04% in RCC

the median age was 55 (range 22 to 78) years. The comparison of the 22 (534.4%) type Ⅰ PRCCs and 42 (65.6%) type Ⅱ PRCCs revealed that type Ⅱ tumors were associated with a greater stage and grade more often. The median follow-up was 46 months (range 19 to 133). Of the 64 patients

14 died

(4.5%) with type Ⅰ and 13 (31.0%) with type Ⅱ tumors (P=0.018). The overall survival rate was 85.7% in type Ⅰ tumors and 55.8% in type Ⅱ tumors

respectively. Univariate analysis identified symptoms at presentation

tumor type

TNM stage and grade as prognostic factors. On multivariate analysis only metastatic RCC remained associated with decreased overall survival (HR:14.78

P=0.004). Conclusion: The percentage of PRCC is lower and type Ⅱ PRCC is relatively common compared with foreign data. Metastasis at diagnosis is an independent predictive parameter of overall survival in Chinese patients with PRCC.