Background and purpose: In recent years

more and more clinical researches on the neuroendocrine carcinoma of the breast were carried out at home and abroad. Although there are quite a lot of the retrieved documents of NEBC at home and abroad

but large-scale reports are rare

besides

the epidemiology

diagnosis

treatment and prognosis were different; more research are needed to analyze NEBC. This paper mainly discussed the NEBC clinical diagnosis

treatment and prognosis. Methods: A retrospective analysis was carried out

25 cases of Tumor Hospital Affiliated to Xinjiang Medical University from Jan. 2004 to Jun. 2013 were pathologically diagnosed as NEBC by clinical data and the follow-up. Results: The average age of 25 NEBC patients was 58.2 years old

without clinical and imaging characteristic features

immunohistochemistry staining showed that

the estrogen receptor (ER) and progesterone receptor (PR) positive rates were 76% and 64%. No one showed HER-2 strong positive. The followup was 9-115 months. Besides

1-

2- and 5-year overall survival (OS) rates were 100%

95% and 88%

the disease-free survival (DFS) rates were 96%

90% and 78%. Conclusion: The age of the patients with NEBC in this study was lower than the data abroad. Age

tumor size

pathological staging may be related to the prognosis of NEBC

and postoperative comprehensive treatment options need further study.