干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移关系

张燕平; 李宁; 邓文英; 韩黎丽; 田沛琦; 许勇飞; 杨姣; 申威; 魏辰; 罗素霞

doi:10.3969/j.issn.1007-3969.2014.09.008

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干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移关系

更新时间：2025-12-31

- 干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移关系
- The expression of SOX-2 and β-catenin in gastric cancer and the relationship with recurrence and metastasis after operation
- 中国癌症杂志 2014年24卷第9期页码：684-689
- 作者机构：
  
  郑州大学附属肿瘤医院内科,河南,郑州,450000
- 作者简介：
- 基金信息：
  
  河南省卫生厅项目(No：2011020171)
- DOI：10.3969/j.issn.1007-3969.2014.09.008
  中图分类号：
- 网络出版：2014-11-12，
  
  纸质出版：2014-11-12
- 稿件说明：
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张燕平,李宁,邓文英,韩黎丽,田沛琦,许勇飞,杨姣,申威,魏辰,罗素霞. 干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移关系[J]. 中国癌症杂志, 2014, 24(9): 684-689.

张燕平, 李宁, 邓文英, et al. The expression of SOX-2 and β-catenin in gastric cancer and the relationship with recurrence and metastasis after operation[J]. China Oncology, 2014, 24(9): 684-689.
张燕平,李宁,邓文英,韩黎丽,田沛琦,许勇飞,杨姣,申威,魏辰,罗素霞. 干细胞标志物SOX-2、β-catenin表达与胃癌术后复发转移关系[J]. 中国癌症杂志, 2014, 24(9): 684-689. DOI： 10.3969/j.issn.1007-3969.2014.09.008.

张燕平, 李宁, 邓文英, et al. The expression of SOX-2 and β-catenin in gastric cancer and the relationship with recurrence and metastasis after operation[J]. China Oncology, 2014, 24(9): 684-689. DOI： 10.3969/j.issn.1007-3969.2014.09.008.

摘要

背景与目的：胃癌术后复发转移严重影响患者生存情况，SOX基因是经典Wnt信号通路的调控因子，其在胃癌术后复发及转移过程中可能发挥重要作用。本研究旨在探讨胃癌术后复发、远处转移患者肿瘤组织中SOX-2、β-catenin表达情况，探讨两者在胃癌术后复发及转移的作用。方法：采用免疫组化方法检测71例经手术切除胃癌患者的肿瘤组织中SOX-2和β-catenin蛋白表达情况，并分析其与临床病理特征和无病生存时间(disease free survival，DFS)的关系。结果：SOX-2在胃癌中的表达与胃癌复发转移、淋巴结浸润及分化程度有关(P=0.011，P=0.036，P=0.034)，与患者性别、年龄及T分期无关。β-catenin在胃癌中的表达与胃癌复发转移、淋巴结浸润及T分期有关(P=0.025，P=0.014，P=0.026)，与分化程度、患者性别及年龄无关。且二者均呈阳性表达者其术后复发转移率高于任意单阳性者，复发转移率分别为84%(21/25)和66.7%(24/36)，二者均阴性表达者其复发转移率为30%(3/10)。生存分析显示SOX-2和β-catenin的表达与患者DFS相关。结论：SOX-2、β-catenin表达可能是胃癌术后复发转移有效的预测因子，两者联合检测有利于预测胃癌患者术后复发转移。

Abstract

Background and purpose: The recurrence and metastasis of gastric cancer seriously affect survival in patients. SOX gene as a regulatory factor of the classical Wnt pathway

may play an important role in the process. This study was to explore the expression of stem cell marker SOX-2 and β-catenin in gastric cancer and to analyze the relationship with recurrence and metastasis after operation. Methods: Immunohistochemistry was used to detect the expression of SOX-2 and β-catenin in 71 tumor samples from 71 cases after surgery for gastric cancer. The correlation between SOX-2 and β-catenin expression and the clinicopathological characteristics of gastric cancer and disease-free survival was analyzed. Results: The SOX-2 protein expression was associated with metastasis

lymph node infiltration or differentiation (P=0.011

P=0.036

P=0.034) in the 71 gastric cancer

but not with gender

age or T stage.β-catenin expression was correlated with metastasis

lymph node invasion or T stage (P=0.025

P=0.014

P=0.026)

but was not related to differentiation

gender or age. The survival analysis showed that SOX-2 and β-catenin expression was closely associated with prognosis of patients

and metastatic rate in positive expression was higher than that in negative expression. Conclusion: The expression of SOX-2 and β-catenin is associated with the development

recurrence

metastasis of gastric cancer and may be used as a useful prognostic parameter to predict overall survival.

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