Multiple myeloma (MM) is a plasma cell malignancy. With the development of the understanding of MM

the diagnosis is no more limited to bone marrow biopsy and imageological examination. Serum free light chain

cytogenetic analysis and molecular biology study are becoming increasingly widely used

which give us a deeper understanding of the mechanisms of MM and provide us with a clearer prognosis evaluation. Here is to make a review of the diagnosis and its development of MM from laboratory examination

diagnosis criteria and classification.