Background and purpose: Nasopharyngeal carcinoma is sensitive with radiotherapy

and it is of great significance to study the resistance mechanism. This study aimed to analyze the expression of TNFAIP3 in the radiotherapy of nasopharyngeal carcinoma

the difference between radiosensitivity and radioresistance

the relationship with the occurrence and development of radioresistance. Methods: Detection of TNFAIP3 mRNA expression was carried out by TNFAIP3 multi-point labeled DIG probe in situ hybridization. Results: In radiosensitivity and radioresistance of nasopharyngeal carcinoma

the moderately and strongly positive TNFAIP3 mRNA expression rates were 15% and 45%

(χ2=5.274

P=0.021 6)

there were statistical significance. In the radioresistat nasopharyngeal carcinoma

TNFAIP3 mRNA moderately and strongly positive expression was positively correlated with TNM stage. In the degree of Ⅲ-Ⅳ tumor

it had moderately and strongly positive expression rate of 48.28%.In the degree of Ⅰ-Ⅱ tumor

it had moderately and strongly positive expression rate of 36.36% (χ2=33.240

P0.005); The expression rates in distant metastasis and no distant metastasis were 81.81% and 31.03% (χ2=6.385

P=0.011 5)

the difference had statistical significance. Conclusion: TNFAIP3 has antitumor effect

and it is correlated with the occurrence and development of radioresistant in nasopharyngeal carcinoma.