结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究

王静文; 韩　韬; 陈　玺

doi:10.3969/j.issn.1007-3969.2015.10.009

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结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究

更新时间：2025-12-31

- 结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究
- The correlation study of beta-fibrinogen gene polymorphisms and plasma fibrinogen concentration in patients with colorectal cancer
- 中国癌症杂志 2015年25卷第10期页码：807-811
- 作者机构：
  
  复旦大学附属华东医院肿瘤科,上海,200040
- 作者简介：
- 基金信息：
  
  上海市卫生计生委员会科研资助项目(20114209)。
- DOI：10.3969/j.issn.1007-3969.2015.10.009
  中图分类号：
- 网络出版：2015-12-17，
  
  纸质出版：2015-12-17
- 稿件说明：
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王静文,韩　韬,陈　玺,等. 结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究[J]. 中国癌症杂志, 2015, 25(10): 807-811.

王静文, 韩　韬, 陈　玺. The correlation study of beta-fibrinogen gene polymorphisms and plasma fibrinogen concentration in patients with colorectal cancer[J]. China Oncology, 2015, 25(10): 807-811.
王静文,韩　韬,陈　玺,等. 结直肠癌患者β-纤维蛋白原基因多态性和血浆纤维蛋白原水平相关性的研究[J]. 中国癌症杂志, 2015, 25(10): 807-811. DOI： 10.3969/j.issn.1007-3969.2015.10.009.

王静文, 韩　韬, 陈　玺. The correlation study of beta-fibrinogen gene polymorphisms and plasma fibrinogen concentration in patients with colorectal cancer[J]. China Oncology, 2015, 25(10): 807-811. DOI： 10.3969/j.issn.1007-3969.2015.10.009.

摘要

背景与目的：结直肠癌患者病程中常伴有血浆纤维蛋白原(fibrinogen，Fg)浓度的升高。该研究探讨结直肠癌人群中FGBβ基因-448G/A、-148C/T、-1420G/A、-854G/A的单核苷酸多态性(single nucleotide polymorphism，SNP)频率分布和血浆Fg浓度的关系，分析其对肿瘤发生、发展的影响。方法：采集194例结直肠癌患者和74例健康者外周血，用实时荧光定量多聚酶链反应(real-time fluorescence quantitative PCR，RTFQ-PCR)法分析FGBβ基因频率分布，用Clauss凝固法检测血浆Fg浓度。结果：结直肠癌转移组和无转移组的血浆Fg浓度均较对照组显著升高(P0.05)。疾病组中FGBβ-148T等位基因频率和突变型基因频率均显著高于对照组(P0.05)。各组人群中FGBβ-148T携带者的血浆Fg浓度均明显高于非携带者(P0.05)。在Ⅳ期患者中FGBβ-148C/T突变型者中位PFS较野生型者差异无统计学意义(P0.05)。结论：结直肠癌患者体内Fg浓度升高，提示其可能参与恶性肿瘤发生、发展的过程。FGBβ-148C/T位点的SNP是导致血浆Fg浓度改变的原因之一，但与Ⅳ期患者的预后无关。

Abstract

Background and purpose: Patients with colorectal cancer are often accompanied by the increase of plasma fibrinogen concentration. This study aimed to investigate the distribution characteristics of beta-fibrinogen gene-448G/A

-148C/T

-1420G/A and -854G/A polymorphism and plasma fibrinogen (Fg) concentration in patients with colorectal cancer. Furthermore

we analyzed their effects on the occurrence and development of cancer. Methods: The level of plasma Fg was quantified by using Clauss clotting method. FGBβ gene polymorphisms were identified by real-time fluorescence quantitative PCR (RTFQ-PCR) in 194 colorectal cancer patients and 74 healthy controls. Results: The plasma Fg levels in tumor metastasis group and non-metastasis group were significantly higher than that in control group

respectively (P0.05). Compared with control group

the frequencies of -148T allele and mutation genotype were notably higher in disease group (P0.05). In all the groups

the plasma Fg levels of those with -148T allele were higher than those without -148T allele (P0.05). In stage Ⅳ patients

there was no difference in PFS between -148T wild genotype group and mutation genotype group (P0.05). Conclusion: Plasma Fg concentration in patients with colorectal cancer was significantly raised

which suggests that Fg may play a role in the occurrence and development of colorectal cancer. The beta-fibrinogen gene -148C/T polymorphism is one of the reasons that cause plasma Fg elevation

but has no correlation with prognosis of patients with stage Ⅳ colorectal cancer. cancer was significantly raised

which suggests that Fg may play a role in the occurrence and development of colorectal cancer. The beta-fibrinogen gene -148C/T polymorphism is one of the reasons that cause plasma Fg elevation

but has no correlation with prognosis of patients with stage Ⅳ colorectal cancer.

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