Chemotherapy is the main treatment approach for advanced colorectal cancer. The 5-fluorouracil (5-FU)
oxaliplatin and irinotecan are three major chemotherapeutic drugs. The combined chemotherapy and “stop and go” treatment mode increase the efficacy and patients’ tolerance. The new drugs
raltitrexed
S-1 and TAS-102
have been approved for use in cancer treatment. This article reviews the new development in chemotherapy for the treatment of advanced colorectal cancer.