中国癌症杂志 ›› 2022, Vol. 32 ›› Issue (9): 779-785.doi: 10.19401/j.cnki.1007-3639.2022.09.004

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胃肠胰神经内分泌肿瘤临床前模型的研究进展

崔灵珺1,2(), 田超1,2, 程梓轩1,2, 郑佳彬2, 苏菲2, 谭煌英2()   

  1. 1.北京中医药大学研究生院,北京 100029
    2.中日友好医院中西医结合肿瘤内科,北京 100029
  • 收稿日期:2022-07-01 修回日期:2022-08-05 出版日期:2022-09-30 发布日期:2022-10-24
  • 通信作者: 谭煌英
  • 作者简介:崔灵珺(ORCID: 0000-0003-3690-7117),学士。
    谭煌英,中日友好医院中西医结合肿瘤内科主任医师、教授,北京中医药大学/北京协和医学院博士研究生导师,中国抗癌协会胰腺癌专业委员会神经内分泌肿瘤学组副组长,中国临床肿瘤学会神经内分泌肿瘤专家委员会委员,中国医疗保健国际交流促进会神经内分泌肿瘤分会常务委员,中国抗癌协会整合肿瘤学分会常务委员,中国研究型医院学会肿瘤学专业委员会委员,北京中西医结合学会肿瘤专业委员会委员,中日友好医院神经内分泌肿瘤诊疗中心负责人,《中国临床肿瘤学会神经内分泌肿瘤诊疗指南(2021年版)》专家组副组长,《中国抗癌协会神经内分泌肿瘤诊治指南(2022年版)》编撰小组副主编,欧洲神经内分泌肿瘤学会会员。专注于神经内分泌肿瘤的诊断及中西医治疗,主持国家自然科学基金面上项目2项,参加国家重点研发计划项目1项。以通信作者或第一作者发表文章60余篇。
  • 基金资助:
    国家重点研发计划(2019YFB1309704)

Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm

CUI Lingjun1,2(), TIAN Chao1,2, CHENG Zixuan1,2, ZHENG Jiabin2, SU Fei2, TAN Huangying2()   

  1. 1. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2022-07-01 Revised:2022-08-05 Published:2022-09-30 Online:2022-10-24
  • Contact: TAN Huangying

摘要:

胃肠胰神经内分泌肿瘤(gastroenteropancreatic neuroendocrine neoplasm,GEP-NEN)是一种近年来发病率逐年升高的罕见异质性肿瘤,根据其分化程度,可分为神经内分泌瘤(neuroendocrine tumor,NET)和神经内分泌癌(neuroendocrine carcinoma,NEC)。随着对其发病机制和治疗手段的探索逐渐加深,临床前模型的重要性日渐凸显。本文就目前已发表的细胞系、类器官模型、人源肿瘤异种移植物模型及基因工程小鼠模型等临床前模型进行综述,并探讨这些模型目前的实际应用情况及其优缺点,旨在为未来研究提供新的思路和方向。

关键词: 胃肠胰神经内分泌肿瘤, 细胞系, 类器官模型, 人源肿瘤异种移植模型, 基因工程小鼠模型

Abstract:

Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods, the importance of preclinical models has become increasingly prominent. Here we reviewed the published preclinical models such as cell lines, organoid models, patient-derived xenograft models and genetically engineered mouse models. We also discussed the current practical applications of these models and their strengths and weaknesses, to provide threads and directions for future research.

Key words: Gastroenteropancreatic neuroendocrine neoplasm, Cell line, Organoid model, Patient-derived xenograft model, Genetically engineered mouse model

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