中国癌症杂志 ›› 2015, Vol. 25 ›› Issue (11): 877-889.doi: 10.3969/j.issn.1007-3969.2015.11.007

• 特约专家述评及综述 • 上一篇    下一篇

晚期结直肠癌的化疗进展

李文桦 综述,张 文 审校   

  1. 复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海 200032
  • 出版日期:2015-11-30 发布日期:2016-02-01
  • 通信作者: 张文 E-mail:zw65242@163.com

Advances in chemotherapy for advanced colorectal cancer

LI Wenhua, ZHANG Wen   

  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2015-11-30 Online:2016-02-01
  • Contact: ZHANG Wen E-mail: zw65242@163.com

摘要:

化疗是晚期结直肠癌的主要治疗手段,以氟尿嘧啶(5-fluorouracil,5-FU)、奥沙利铂和伊立替康为主的三药是晚期肠癌治疗的重要药物,联合化疗和“打打停停”的治疗模式在提高疗效的同时兼顾了治疗的耐受性。新的化疗药物雷替曲塞、替吉奥和TAS-102也在临床中获得应用。就晚期结直肠癌化疗的进展进行综述。

关键词: 结直肠癌, 化疗, 转移

Abstract: Chemotherapy is the main treatment approach for advanced colorectal cancer. The 5-fluorouracil (5-FU), oxaliplatin and irinotecan are three major chemotherapeutic drugs. The combined chemotherapy and “stop and go” treatment mode increase the efficacy and patients’ tolerance. The new drugs, raltitrexed, S-1 and TAS-102, have been approved for use in cancer treatment. This article reviews the new development in chemotherapy for the treatment of advanced colorectal cancer.

Key words: Colorectal cancer, Chemotherapy, Metastases