氨基酸代谢重编程在结直肠癌肝转移中的研究进展

王尔聪; 闫军钱; 贾夏鹤; 王伊彤; 陈涛; 姜雷; 王军

doi:10.19401/j.cnki.1007-3639.2026.09.009

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氨基酸代谢重编程在结直肠癌肝转移中的研究进展

综述 | 更新时间：2026-10-23

- 氨基酸代谢重编程在结直肠癌肝转移中的研究进展
- Research advances in amino acid metabolic reprogramming in colorectal cancer liver metastasis
- 中国癌症杂志 2026年36卷第9期页码：902-910
- 作者机构：
  
  1.兰州大学第一临床医学院，甘肃兰州 730000
  2.兰州大学基础医学院，甘肃兰州 730000
  3.兰州大学第一医院普外科，甘肃兰州 730000
- 作者简介：
  
  WANG Jun　E-mail: juan_phd@163.com
- 基金信息：
  
  癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(2024ZD0520304)
- DOI：10.19401/j.cnki.1007-3639.2026.09.009
  中图分类号： R735.3+5;R735.3+7
- 收稿：2025-12-25，
  
  修回：2026-04-28，
  
  纸质出版：2026-09-30
- 稿件说明：
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王尔聪, 闫军钱, 贾夏鹤, 等. 氨基酸代谢重编程在结直肠癌肝转移中的研究进展［J］. 中国癌症杂志, 2026, 36（9）: 902-910.

Wang E C, Yan J Q, Jia X H, et al. Research advances in amino acid metabolic reprogramming in colorectal cancer liver metastasis［J］. Chin Oncol, 2026, 36（9）: 902-910.
王尔聪, 闫军钱, 贾夏鹤, 等. 氨基酸代谢重编程在结直肠癌肝转移中的研究进展［J］. 中国癌症杂志, 2026, 36（9）: 902-910. DOI： 10.19401/j.cnki.1007-3639.2026.09.009.

Wang E C, Yan J Q, Jia X H, et al. Research advances in amino acid metabolic reprogramming in colorectal cancer liver metastasis［J］. Chin Oncol, 2026, 36（9）: 902-910. DOI： 10.19401/j.cnki.1007-3639.2026.09.009.

摘要

结直肠癌（colorectal cancer，CRC）在全球范围内发病率高、疾病负担重，且极易发生远处转移，其中肝脏转移最为常见。代谢重编程（metabolic reprogramming，MRP）是指细胞为了适应内外环境的变化（如营养供应、能量需求、生长信号、应激压力等），主动地改变其代谢通路和能量产生方式的过程，是恶性肿瘤发生、发展的重要特征之一。在此过程中，肿瘤细胞（尤其是转移灶细胞）的氨基酸代谢发生显著重编程，通过获取能量、生物合成前体及维持氧化还原平衡，以适应恶劣微环境并促进转移灶形成。这种现象在CRC肝转移（CRC liver metastasis，CRLM）患者中同样普遍存在。深入分析CRLM患者原发灶、转移灶及其周围肿瘤微环境（tumor microenvironment，TME）中的氨基酸代谢变化，将有助于寻找CRLM的早期诊断标志物、确立治疗策略及发现新的治疗靶标。本文系统总结CRLM中氨基酸MRP的最新研究进展，重点阐述其通过调控关键代谢酶和氨基酸转运体驱动肿瘤进展，并进一步梳理基于氨基酸代谢的诊断标志物及多种新型靶向药物和治疗靶点，为CRLM的精准诊断与治疗提供新的理论依据和潜在转化方向。

Abstract

Colorectal cancer (CRC) is characterized by high global incidence and substantial disease burden

with a marked propensity for distant metastasis

most commonly to the liver. Metabolic reprogramming (MRP) is a fundamental hallmark of malignant tumor progression. During this process

amino acid metabolism in tumor cells

particularly at metastatic sites

undergoes substantial reprogramming. This adaptation allows cells to acquire energy and biosynthetic precursors while maintaining redox balance

thereby enabling their survival in harsh microenvironments and promoting metastasis formation. This phenomenon is commonly observed in patients with CRC liver metastasis (CRLM). In-depth analysis of amino acid metabolic alterations in primary tumors

metastatic lesions

and the surrounding tumor microenvironment (TME) in patients with CRLM offers significant potential for identifying early diagnostic biomarkers

developing treatment strategies

and uncovering novel therapeutic targets. This review summarizes recent advances in amino acid MRP in CRLM

highlighting that tumor progression is predominantly driven by the regulation of key metabolic enzymes and amino acid transporters. In addition

emerging diagnostic biomarkers and several novel therapeutic targets and metabolic inhibitors are discussed

providing new insights for precision diagnosis and targeted treatment of CRLM.

关键词

Keywords

references

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