Background and purpose: The study analyzed 1-

3- and 5-year observed overall survival (OS) and disease-free survival (DFS)

providing real world evidence of long-term survival among Chinese surgical colorectal cancer patients. Methods: A total of 13 721 colorectal cancer patients undergoing surgery in Fudan University Shanghai Cancer Center (FUSCC) from Jan. 1

2008 to Dec. 31

2017 were included in the analysis. Medical records review

telephone visits and death registry data linkage were carried out for collecting endpoint data. The last follow-up date was Nov. 30

2019. Kaplan-Meier method was used to evaluate the 1-

3-

and 5-year OS and DFS

and data were stratified by age group

gender

staging

calendar period

pathological characteristics and treatment approaches. Results: With a median follow-up time of 54.03 months

the 5-year OS of all patients and DFS of 0-Ⅲ stage surgical colorectal cancer patients were 73.87% and 72.25%

respectively. The 5-year OS of stage 0-Ⅰ

Ⅱ

Ⅲ and Ⅳ colorectal cancer patients were 91.92%

87.15%

70.49% and 27.70%

respectively. The OS of patients aged less than 45 years was 74.93%

poorer than 45-64 and 65-74 age category. There were significant difference in OS and DFS among different histology types

differentiation

extermural vascular invasion

perineural invasion and circumferential radial margin. Conclusion: It is the first single institutional long term survival report of over 10 thousand colorectal cancer patients. Young patients aged less than 45 years had a poor prognosis. Staging is an important modifiable factor

which implies that enhancing screening and early diagnosis has important meaning to further improve the patients’ survival.