Background and purpose: This study aimed to explore the influences on quality of life of patients with breast cancer in different stages undergone different styles of operations. Methods: During Apr. 2012 and Apr. 2013

a total number of 207 patients with breast cancer

including 61 patients undergone breast conserving surgery (BCS)

60 patients undergone immediate breast reconstruction (IBR) and 86 patients undergone modified radical mastectomy (MRM) reviewed or admitted in Beijing Tongren Hospital Affiliated to Capital Medical University were included in the research

in which FACT-B

SAS and SDS were used to assess the quality of life and negative emotions performing as the paired design. Results: The physical well-being

emotional well-being and the level of negative emotions such as anxiety and depression revealed significant differences compared the patients who undergone BCS or IBR with those who undergone MRM in preoperative period (P0.05)

and there was no statistical difference in terms of other quality of life (P0.05). At two and five years postoperatively

there was no significant in the physical well-being

emotional well-being and negative emotions (P0.05)

whereas there was significant differences in the other quality of life (P0.05). Conclusion: BCS and IBR compared with MRM can obviously reduce the levels of preoperative negative emotions such as anxiety and depression

and improve the quality of life in long-term (two and five years postoperatively) to some degree.