关键词: 局部晚期宫颈癌, 生存率, 医院登记

Abstract: Background and purpose: The study described hospital-based follow-up data of cervical cancer to investigate the long-term survival of locally advanced cervical cancer (LACC) patients in China. Methods: A total of 1 313 cases of cervical cancer with clinical stages of ⅠB2 and ⅡA2, diagnosed and treated from 2006 to 2013 in Fudan University Shanghai Cancer Center, were included. Medical records review, telephone follow-up and death registry data linkage were applied for collecting follow-up information. The last follow-up date was Nov. 30, 2019. The median follow-up time was 71 months. Life-table was used to estimate the 1-year, 3-year, 5-year and 10-year overall survival (OS) rates and disease-free survival (DFS) rates, stratified by age group and clinical stage. Results: The average age of LACC patients was 45 years. The 5-year OS rate was 77.69% (95% CI: 75.1%-80.1%), and 10-year OS rate was 72.5% (95% CI: 69.2%-75.7%). The 5-year and 10-year DFS rates were 74.0% and 71.0% respectively. Both OS and DFS rates in stage ⅠB2 were significantly higher than those in stage ⅡA2. DFS rates were significantly different among age groups, with the highest DFS rate observed in 35-44 age group. Conclusion: The recurrence, metastasis and death of LACC mainly occurred within 5 years after treatment. The survival of LACC in China was stable in the past decade. More attention should be paid to clinical management and prognosis for young LACC patients.

Key words: Locally advanced cervical cancer, Survival rate, Hospital registration