2022年度肾细胞癌基础研究及临床诊疗新进展

doi:10.19401/j.cnki.1007-3639.2023.03.001

摘要/Abstract

摘要：

肾细胞癌（renal cell carcinoma，RCC）是泌尿系统三大肿瘤之一，随着生活方式的改变以及肥胖、高血压等系统疾病的增多，中国的RCC发病率也呈逐年上升趋势。RCC起病隐匿，大多数RCC患者是通过影像学检查偶然发现的，不少患者确诊时已是晚期。虽然靶向治疗和免疫治疗的出现显著延长了晚期RCC患者的生存时间，但RCC病理学类型众多，许多RCC患者仍难以从系统性治疗中获益。大量基础和临床研究致力于探索新的靶点及治疗药物，以进一步改善患者的预后。本文总结2022年度RCC研究和诊疗新进展，旨在为临床诊治提供新思路。

关键词: 肾细胞癌, 免疫治疗, 靶向治疗, 基础研究, 临床研究

Abstract:

Renal cell carcinoma (RCC) is one of the three major urinary system tumors. With the changes of lifestyle and the rise of obesity, hypertension and other diseases, the incidence of RCC is increasing. The onset of RCC is hidden, and RCC has strong heterogeneity. Most RCC patients are found accidentally by imaging examination, so many patients were diagnosed in the advanced stage. Although the emergence of targeted therapy and immunotherapy has greatly prolonged the survival time of patients with advanced RCC, due to many pathological types of RCC, it is still difficult for many patients to benefit from the systematic treatment. Many basic and clinical studies are devoted to the development of new targets or drugs to prolong the survival time of patients. This article reviewed the advances in the research, diagnosis and treatment of RCC in 2022.

Key words: Renal cell carcinoma, Immunotherapy, Targeted therapy, Basic research, Clinical research

中图分类号:

R737.11

田熙, 徐文浩, 朱殊璇, 艾合太木江·安外尔, 宿佳琦, 叶世琪, 瞿元元, 施国海, 张海梁, 叶定伟. 2022年度肾细胞癌基础研究及临床诊疗新进展[J]. 中国癌症杂志, 2023, 33(3): 191-200.

TIAN Xi, XU Wenhao, ZHU Shuxuan, AIHETAIMUJIANG•Anwaier, SU Jiaqi, YE Shiqi, QU Yuanyuan, SHI Guohai, ZHANG Hailiang, YE Dingwei. Advances in the research, diagnosis and treatment of renal cell carcinoma in 2022[J]. China Oncology, 2023, 33(3): 191-200.

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