Predictive value of CEA and CA19-9 for recurrence in stage Ⅱ-Ⅲ colon cancer

LIN Xuedan; YANG Tianxing; TAO Zhihua

doi:10.19401/j.cnki.1007-3639.2018.11.005

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Predictive value of CEA and CA19-9 for recurrence in stage Ⅱ-Ⅲ colon cancer

更新时间：2026-01-27

- Predictive value of CEA and CA19-9 for recurrence in stage Ⅱ-Ⅲ colon cancer
- China Oncology Vol. 28, Issue 11, Pages: 827-832(2018)
- 作者机构：
  
  1. 浙江大学医学院附属第二医院检验科,浙江,杭州,310009
  2. 浙江省三门县中医院检验科,浙江,台州,317100
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.11.005
  CLC：
- Published Online：14 December 2018，
  
  Published：14 December 2018
- 稿件说明：
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林雪丹,杨天兴,陶志华. 癌胚抗原和糖类抗原19-9对Ⅱ~Ⅲ期结肠癌复发的预测价值[J]. 中国癌症杂志, 2018, 28(11): 827-832.

LIN Xuedan, YANG Tianxing, TAO Zhihua. Predictive value of CEA and CA19-9 for recurrence in stage Ⅱ-Ⅲ colon cancer[J]. China Oncology, 2018, 28(11): 827-832.
林雪丹,杨天兴,陶志华. 癌胚抗原和糖类抗原19-9对Ⅱ~Ⅲ期结肠癌复发的预测价值[J]. 中国癌症杂志, 2018, 28(11): 827-832. DOI： 10.19401/j.cnki.1007-3639.2018.11.005.

LIN Xuedan, YANG Tianxing, TAO Zhihua. Predictive value of CEA and CA19-9 for recurrence in stage Ⅱ-Ⅲ colon cancer[J]. China Oncology, 2018, 28(11): 827-832. DOI： 10.19401/j.cnki.1007-3639.2018.11.005.

摘要

背景与目的：Ⅱ~Ⅲ期结直肠癌患者根治术后约有1/3出现复发转移，影响患者预后。该研究旨在评估癌胚抗原（carcinoembryonic antigen，CEA）和糖类抗原19-9（carbohydrate antigen 19-9，CA19-9）对Ⅱ~Ⅲ期结肠癌患者根治术后复发的预测价值。方法：回顾性分析2012—2013年收治的168例Ⅱ~Ⅲ期结肠癌患者的临床病理和随访资料，均接受根治术，根据术前和术后血清CEA和CA19-9结果将患者分成3组。结果：CEA（H）组的无复发生存率显著低于CEA（HN）组和CEA（N）组（7.4% vs 52.5% vs 75.0%，P=0.000），CA19-9（H）组的无复发生存率显著低于CA19-9（HN）组和CA19-9（N）组（7.1% vs 50.0% vs 61.9%，P=0.000）；COX比例风险回归模型多因素分析显示，CEA（H）组、CEA（HN）组、CA19-9（H）组及淋巴结转移是Ⅱ~Ⅲ期结肠癌根治术后复发的独立危险因素。结论：血清CEA和CA19-9可以作为Ⅱ~Ⅲ期结肠癌患者预测复发、协助TNM分期判断预后的重要指标。

Abstract

Background and purpose: About one third of patients with stage Ⅱ-Ⅲ colorectal cancer suffer a recurrence after radical surgery

which affects the prognosis of patients. This study aimed to evaluate the value of serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in predicting and monitoring the recurrence of stage Ⅱ-Ⅲ colon cancer patients after radical surgery. Methods: The clinicopathological and follow-up data collected from 168 patients who underwent radical resection of stage Ⅱ-Ⅲ colon cancer from 2012 to 2013 were analyzed retrospectively. The patients were divided into 3 groups based on the results of serum CEA and CA19-9 before and after surgery. Results: The recurrence-free survival rate in the CEA (H) group was lower than in the CEA (HN) group and CEA (N) group (7.4% vs 52.5% vs 75.0%

P=0.000). The recurrence-free survival rate in the CA19-9 (H) group was lower than in the CA19-9 (HN) group and CA19-9 (N) group (7.1% vs 50.0% vs 61.9%

P=0.000). Multivariate analysis showed that CEA (H) group

CEA (HN) group

CA19-9 (H) group and lymph node metastasis were independent risk factors for recurrence after radical resection in stage Ⅱ-Ⅲ colon cancer patients. Conclusion: Serum CEA and CA19-9 can be used as predictive factors for recurrence in stage Ⅱ-Ⅲ colon cancer patients and assist in the TNM staging for prognosis of the patients.

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