62例输卵管癌临床和病理预后分析

doi:10.19401/j.cnki.1007-3639.2017.10.004

中国癌症杂志 ›› 2017, Vol. 27 ›› Issue (10): 782-788.doi: 10.19401/j.cnki.1007-3639.2017.10.004

62例输卵管癌临床和病理预后分析

黄建琴¹，肖银平²，朱芝玲¹

1. 复旦大学附属妇产科医院中西医结合科，上海 200090 ；
2. 复旦大学附属妇产科医院病理科，上海 200090

出版日期:2017-10-30 发布日期:2017-12-05
通信作者: 朱芝玲 E-mail：zhilingzhu888@126.com

Clinical and pathological prognostic analysis of 62 patients with fallopian tube carcinoma

HUANG Jianqin¹, XIAO Yinping², ZHU Zhiling¹

1. Department of Integrative Medicine, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China; 2. Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200090, China

Published:2017-10-30 Online:2017-12-05
Contact: ZHU Zhiling, E-mail: zhilingzhu888@126.com

摘要/Abstract

摘要： 背景与目的：输卵管癌是妇科罕见的恶性肿瘤，预后较差。该研究通过回顾性分析探讨了输卵管癌的各临床和病理因素对预后的影响，从而为治疗提供依据。方法：回顾性评价62例输卵管癌患者各临床和病理因素对预后的影响。应用Kaplan-Meier方法计算生存期，log-rank检验进行组间比较。通过应用COX比例风险模型对单因素分析有意义的因素进行多因素分析，筛选出有独立显著意义的预后因素。结果：62例输卵管癌患者中位生存期为74个月，3年生存率为78%，5年生存率为63%。国际妇产科联盟(International Federation of Gynaecology and Obstetrics，FIGO)分期、术后残余肿瘤大小、化疗次数是输卵管癌的独立预后因素。P53蛋白阴性者中位生存时间、3和5年生存率均高于P53蛋白阳性者。Ki-67平均比例为58.41%，Ki-67小于等于58%者中位生存时间、3和5年生存率数值上均高于Ki-67大于58%者。结论：输卵管癌的分期、术后残余肿瘤的大小和化疗次数是输卵管癌的独立预后因素。早期诊断，从而早期治疗是改善预后的关键因素。争取肿瘤细胞减灭术最大程度的彻底性，术后予有效、足疗程的化疗才能真正提高输卵管癌患者的生存率。病理检查，尤其是P53蛋白和Ki-67的表达水平，对判断输卵管癌预后有一定的意义。

关键词: 输卵管癌, 临床, 病理, 预后

Abstract: Background and purpose: Fallopian tube carcinoma is a rare malignant tumor of gynecology with a poor prognosis. In this paper, the clinical and pathological factors affecting the prognosis of fallopian tube carcinoma were analyzed retrospectively. Methods: Effects of clinical and pathological factors on prognosis in 62 patients with fallopian tube carcinoma were retrospectively evaluated. Kaplan-Meier method was used to calculate the survival time, and log-rank test was used for comparison between groups. COX proportional hazards model was used to analyze the significant factors of single factor analysis. Results: The median survival time of 62 patients with fallopian tube carcinoma was 74 months, the 3-year survival rate was 78% and the 5-year survival rate was 63%. International Federation of Gynaecology and Obstetrics (FIGO) stage, postoperative residual tumor size, and number of courses of chemotherapy were the independent prognostic factors in patients with fallopian tube carcinoma. The median survival time, 3-year and 5-year survival rates of P53-negative patients were higher than those of P53-positive patients. The average ratio of Ki-67 was 58.41%, and the median survival time, 3-year and 5-year survival rates of patients with Ki- 67≤58% numerically were higher than those of patients with Ki-67>58%. Conclusion: FIGO stage, postoperative residual tumor size, and number of courses of chemotherapy are the independent prognostic factors in patients with fallopian tube carcinoma. Early diagnosis and early treatment are the key factors to improve the prognosis. Striving for the greatest degree of thoroughness of cytoreductive surgery, followed by an effective and full course of chemotherapy, can improve the survival rate of patients with fallopian tube carcinoma. Pathological examinations, especially the expression levels of p53 protein and Ki-67, have a certain significance in judging the prognosis of fallopian tube carcinoma.

Key words: Fallopian tube carcinoma, Clinical, Pathology, Prognosis

黄建琴,肖银平,朱芝玲. 62例输卵管癌临床和病理预后分析[J]. 中国癌症杂志, 2017, 27(10): 782-788.

HUANG Jianqin, XIAO Yinping, ZHU Zhiling. Clinical and pathological prognostic analysis of 62 patients with fallopian tube carcinoma[J]. China Oncology, 2017, 27(10): 782-788.

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62例输卵管癌临床和病理预后分析

Clinical and pathological prognostic analysis of 62 patients with fallopian tube carcinoma

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