关键词: TNFAIP3基因, 放疗敏感, 放疗抗拒, 鼻咽癌

Abstract:

Background and purpose: Nasopharyngeal carcinoma is sensitive with radiotherapy, and it is of great significance to study the resistance mechanism. This study aimed to analyze the expression of TNFAIP3 in the radiotherapy of nasopharyngeal carcinoma, the difference between radiosensitivity and radioresistance, the relationship with the occurrence and development of radioresistance. Methods: Detection of TNFAIP3 mRNA expression was carried out by TNFAIP3 multi-point labeled DIG probe in situ hybridization. Results: In radiosensitivity and radioresistance of nasopharyngeal carcinoma, the moderately and strongly positive TNFAIP3 mRNA expression rates were 15% and 45%, (χ2=5.274, P=0.021 6), there were statistical significance. In the radioresistat nasopharyngeal carcinoma, TNFAIP3 mRNA moderately and strongly positive expression was positively correlated with TNM stage. In the degree of Ⅲ-Ⅳ tumor, it had moderately and strongly positive expression rate of 48.28%.In the degree of Ⅰ-Ⅱ tumor, it had moderately and strongly positive expression rate of 36.36% (χ2=33.240, P<0.005); The expression rates in distant metastasis and no distant metastasis were 81.81% and 31.03% (χ2=6.385, P=0.011 5), the difference had statistical significance. Conclusion: TNFAIP3 has antitumor effect, and it is correlated with the occurrence and development of radioresistant in nasopharyngeal carcinoma.

Key words: TNFAIP3 gene, Radiosensitivity, Radioresistance, Nasopharyngeal carcinoma