中国癌症杂志 ›› 2016, Vol. 26 ›› Issue (1): 117-120.doi: 10.3969/j.issn.1007-3969.2016.01.019

• 综述 • 上一篇    

长链非编码RNA在泌尿系统肿瘤中的研究进展

朱一平 综述 叶定伟 审校   

  1. 复旦大学附属肿瘤医院泌尿外科,复旦大学上海医学院肿瘤学系,上海200032
  • 出版日期:2016-01-30 发布日期:2016-02-26
  • 通信作者: 叶定伟 E-mail:dwyeli@163.com
  • 基金资助:
    国家自然科学基金青年项目(81302216);教育部博士点基金(20130071110056)。

Long noncoding RNAs in urological neoplasms

ZHU Yiping, YE Dingwei   

  1. Department of Urology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2016-01-30 Online:2016-02-26
  • Contact: YE Dingwei E-mail: dwyeli@163.com

摘要: 长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200个的核苷酸,并不具备编码蛋白质功能的基因转录产物。它最初被认为是RNA聚合酶Ⅱ转录的副产物,并不具有任何生物学功能。但最近的研究表明,lncRNA可以在多个层面参与人体内多种重要的调控过程,并且与肿瘤的发生、发展及预后密切相关。本研究对在泌尿系统肿瘤中的研究进展作一综述。

关键词: 长链非编码RNA, 泌尿系统肿瘤, 基因表达

Abstract: Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nt without coding capacities. Although they were initially argued to be transcriptional by-products of RNA polymerase Ⅱ, recent evidence suggests that lncRNAs have been associated with a spectrum of biological processes, and aberrant lncRNA expression may be a major contributor to tumorigenesis, progression and prognosis. This study summarizes the up-to-date studies on lncRNAs in urological neoplasms.

Key words: Long non-coding RNAs, Urological neoplasms, Gene expression