• 综述 •

### 炎症与免疫指标在可切除性结直肠癌中的预后价值

1. 1. 华中科技大学同济医学院附属湖北肿瘤医院胃肠肿瘤外科，湖北 武汉 430079 ；
2. 湖北省结直肠癌临床医学研究中心，湖北 武汉 430079 ；
3. 武汉市结直肠癌临床医学研究中心，湖北 武汉 430079 ；
4.华中科技大学同济医学院附属湖北肿瘤医院腹部肿瘤科，湖北 武汉 430079
• 出版日期:2021-09-30 发布日期:2021-10-08
• 通信作者: 魏少忠 E-mail: weishaozhong@163.com
• 基金资助:
国家重点研发计划资助（2017YFC0908204）；湖北省技术创新专项（重大项目）（2019ACA135）；湖北省卫健委联合基金重点项目（WJ2019H121）；湖北省卫健委重点项目（WJ2021Z001）。

### Prognostic value of inflammatory and immune markers in resectable colorectal cancer

MA Yifei 1,2,3 , LIANG Xinjun 2,3,4 , WEI Shaozhong 1,2,3

1. 1. Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, Hubei Province, China; 2. Colorectal Cancer Clinical Research Center of Hubei Province, Wuhan 430079, Hubei Province, China; 3. Colorectal Cancer Clinical Research Center of Wuhan, Wuhan 430079, Hubei Province, China; 4. Department of Abdominal Oncology, Hubei Cancer Hospital Affiliated of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, Hubei Province, China
• Published:2021-09-30 Online:2021-10-08
• Contact: WEI Shaozhong E-mail: weishaozhong@163.com

Abstract: Colorectal cancer is one of the most common malignant tumors in the world. The incidence and mortality of colorectal cancer are increasing year by year in China, and the trend of younger age is becoming more and more obvious. Immune and inflammation-mediated anti-tumor responses are particularly important in the process of tumor treatment, and play an important role in the multi-stage development of tumors. In recent years, researchers have found that neutrophil-lymphocyte ratio (NLR), platelet- lymphocyte ratio (PLR) and prognostic nutritional index (PNI), which are systemic inflammatory markers, can guide the prognosis of patients undergoing radical colorectal cancer surgery. In addition, tumor-infiltrating lymphocytes (TIL) and tumor-associated macrophages (TAM) have also become a focus of research. As early as 2005, scholars found that for patients with colorectal cancer undergoing radical resection, the infiltrating lymphocytes in the tumor tissues were related to the prognosis of these patients, and the higher the density of infiltrating lymphocytes, the better the prognosis of the patients. In recent years, more and more studies have been conducted to verify these conclusions and explore the underlying mechanism. Traditional TNM staging system has been widely used to predict the prognosis of patients with colorectal cancer, however, it represents the biological behavior of the tumor and cannot accurately predict the risk of death and recurrence of patients with colorectal cancer. Some studies have established an individualized prediction model and visualized the prediction model by using the nomogram to predict the prognosis of resectable colorectal cancer patient with higher efficiency. This paper aimed to explore the predictive status of inflammatory markers and immune markers in resectable colorectal cancer, and at the same time, to search for a more efficient prognosis model of colorectal cancer to predict the prognosis of patient with resectable colorectal cancer more accurately.