中国癌症杂志 ›› 2018, Vol. 28 ›› Issue (12): 928-934.doi: 10.19401/j.cnki.1007-3639.2018.12.008

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肿瘤浸润淋巴细胞在三阴性乳腺癌和HER2阳性乳腺癌中作用的最新研究进展

吉 芃,龚 悦,狄根红   

  1. 复旦大学附属肿瘤医院乳腺外科,上海市乳腺肿瘤重点实验室,复旦大学上海医学院肿瘤学系,上海200032
  • 出版日期:2018-12-30 发布日期:2019-01-11
  • 通信作者: 狄根红 E-mail:dgh_2015@126.com

Latest research progress on tumor-infiltrating lymphocytes in HER2-positive and triple-negative breast cancer

JI Peng, GONG Yue, DI Genhong   

  1. Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2018-12-30 Online:2019-01-11
  • Contact: DI Genhong E-mail: dgh_2015@126.com

摘要: 在乳腺癌的所有亚型中,三阴性乳腺癌(triple-negative breast cancer,TNBC)和人表皮生长因子受体2(human epidermal growth factor receptor 2 ,HER2)阳性型乳腺癌的恶性程度较高,越来越多的证据提示这两种亚型肿瘤病灶中肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes,TIL)所占百分比越高,患者的预后越好。但TIL并非单一种类细胞,其复杂的内部细胞成分导致在不同亚型乳腺癌患者或接受不同治疗的乳腺癌患者中,发挥的预后预测作用差异较大。本文就TIL的分类,TIL在TNBC、HER2阳性乳腺癌中的作用和TIL相关免疫治疗策略的最新研究进展作一总结。

关键词: 肿瘤浸润淋巴细胞, 三阴性乳腺癌, HER2阳性乳腺癌, 免疫治疗

Abstract: Triple-negative breast cancer (TNBC) and human epidermal growth factor receptor-2 (HER2)-positive breast cancer are the most aggressive subtypes of breast cancer with higher recurrent rates, distant metastasis rates and poor prognosis. There are increasing evidence suggesting that high level of tumor-infiltrating lymphocytes (TIL) is associated with a more favorable outcome. However, the complex cellular components within TIL have an enormous influence on the prognostic value of TIL in patients with various subtypes or patients receiving different therapies. In this review, we summarized the classification of TIL, the value of TILs in TNBC and HER2-positive breast cancer and immunotherapies related to TIL.

Key words: Tumor-infiltrating lymphocytes, Triple-negative breast cancer, HER2-positive breast cancer, Immunotherapy