关键词: 乳腺癌, 新辅助治疗, 中性粒细胞与淋巴细胞比值, 腋窝淋巴结, 病理学完全缓解

Abstract: Background and purpose: Neutrophil to lymphocyte ratio (NLR) is a simple, objective and inexpensive laboratory indicator, and its predictive value has been verified in different types of cancer. The purpose of this study was to integrate pretreatment indicators including clinical factors with NLR to predict axillary pathological complete response (apCR) after neoadjuvant therapy (NAT). Methods: From April 2016 to April 2020, 416 breast cancer patients with clinical nodal positive disease undergoing operation after NAT were included. The pretreatment clinicopathological factors and laboratory indexes were collected. The optimal cut-off values of age and laboratory indexes were determined by Youden index using receiver operating characteristic (ROC) curve analyses. The logistic regression analysis was applied to examine predictive factors of apCR. Then, a logistic model was developed according to multivariate analysis results, and it was analyzed using ROC curve and area under curve (AUC) value. Results: Among 416 patients, 37.3% (155) of them achieved apCR. The multivariate analysis showed that age (OR=0.528, 95% CI: 0.343-0.814), pathological grade (OR=1.846, 95% CI: 1.187-2.872), molecular subtype (OR=2.791, 95% CI: 1.780-4.377) and NLR (OR=0.302, 95% CI: 0.105-0.867) were indicated as independent predictors of apCR. Based on these factors, we built the logistic model to predict apCR: logit(P)=0.613×pathological grading+1.027×molecular subtype-0.638×age-1.196×NLR-0.244 (model checking χ ² =54.478, P＜ 0.001). The AUC value of the logistic model was 0.702. Conclusion: Except for traditional clinical factors, the NLR level could also be identified as predictive factor of apCR after NAT. Integrating traditional clinical factors with NLR level could help to predict apCR and guide individualized treatment options.

Key words: Breast cancer, Neoadjuvant therapy, Neutrophil to lymphocyte ratio, Axillary lymph node, Pathological complete response