荧光成像技术在口腔癌诊疗中的应用及进展

doi:10.19401/j.cnki.1007-3639.2023.09.008

中国癌症杂志 ›› 2023, Vol. 33 ›› Issue (9): 874-878.doi: 10.19401/j.cnki.1007-3639.2023.09.008

荧光成像技术在口腔癌诊疗中的应用及进展

许弘弢(), 黄小娟, 郑重阳, 张志愿()

上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科，上海交通大学口腔医学院，国家口腔医学中心，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，中国医学科学院口腔颌面再生医学创新单元，上海 200011

收稿日期:2023-02-01 修回日期:2023-05-04 出版日期:2023-09-30 发布日期:2023-10-01
通信作者: 张志愿（ORCID: 0000-0001-8569-7326），博士，教授。
作者简介:许弘弢（ORCID: 0000-0003-3660-284X），硕士。
基金资助:
国家自然科学基金(82002853);上海市口腔疾病临床医学研究中心(19MC1910600);上海市临床重点专科(shslczdzk 01601);中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-037);浙江省医药卫生科技计划项目(2020KY939)

Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer

XU Hongtao(), HUANG Xiaojuan, ZHENG Chongyang, ZHANG Zhiyuan()

Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China

Received:2023-02-01 Revised:2023-05-04 Published:2023-09-30 Online:2023-10-01
Contact: ZHANG Zhiyuan.

摘要/Abstract

摘要：

口腔癌治疗目前面临的主要临床问题是术后复发和转移。如何提高手术切除效率、改善患者预后是实现口腔癌根治的关键。荧光成像技术作为辅助性手段应用于口腔癌的诊断和治疗，能够以非侵入、无辐射的方式提供实时、超高分辨率的影像学资料，达到术前肿瘤识别诊断、术中肿瘤边界确定及术后癌床检查的效果，有助于降低复发率、提高患者生存率和生存质量。本文就应用于口腔癌临床和基础研究的代表性荧光探针及其特点、局限性和应用前景予以综述。

关键词: 口腔癌, 荧光成像技术, 荧光探针, 诊断

Abstract:

The main clinical problems in treatment of oral cancer are tumor recurrence and metastasis after surgery. To improve the efficiency of resection and the prognosis of patients is a key to curing oral cancer. Fluorescence imaging, as an adjuvant in the diagnosis and treatment of oral cancer with no invasion and radiation, can provide real-time and ultrahigh-resolution graphics for preoperative tumor diagnosis, intraoperative tumor margin determination and postoperative tumor bed checking, which can help reduce the recurrent rate, enhance the survival rate and improve the life quality of patients. This article reviewed several typical fluorescent probes and discussed their characteristics, limitations and application prospects in clinic or research for oral cancer.

Key words: Oral cancer, Fluorescence imaging technology, Fluorescent probe, Diagnosis

中图分类号:

R739.85

许弘弢, 黄小娟, 郑重阳, 张志愿. 荧光成像技术在口腔癌诊疗中的应用及进展[J]. 中国癌症杂志, 2023, 33(9): 874-878.

XU Hongtao, HUANG Xiaojuan, ZHENG Chongyang, ZHANG Zhiyuan. Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer[J]. China Oncology, 2023, 33(9): 874-878.

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荧光成像技术在口腔癌诊疗中的应用及进展

Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer

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