中国癌症杂志 ›› 2016, Vol. 26 ›› Issue (8): 704-711.doi: 10.19401/j.cnki.1007-3639.2016.08.011

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肾癌相关长链非编码RNA研究进展

何安邦,陈浩冬,吕兆洁,阳建庚,梅红兵   

  1. 安徽医科大学深圳市第二人民医院临床医学院泌尿外科,广东 深圳 518000
  • 出版日期:2016-08-30 发布日期:2016-10-19
  • 通信作者: 梅红兵 E-mail:hbmei68@163.com
  • 基金资助:
    深圳基础研究项目(JCYJ20150330102720182);深圳市卫生计生系统科研项目(201506026,201601025)。

Research progress on long non-coding RNA in renal cell carcinoma

HE Anbang, CHEN Haodong, LÜ Zhaojie, YANG Jiangeng, MEI Hongbing   

  1. Department of Urology, Shenzhen Second People’s Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518035, Guangzhou Province, China
  • Published:2016-08-30 Online:2016-10-19
  • Contact: MEI Hongbing E-mail: hbmei68@163.com

摘要: 长链非编码RNA(long non-coding RNA,lncRNA)是一类由RNA聚合酶Ⅱ转录及可变剪接而来、长度大于200个核苷酸、无蛋白编码功能的RNA分子。众多研究表明其在表观遗传学、转录等水平发挥重要的调控作用,且其异常表达与肾癌(renal cell carcinoma,RCC)的发生、发展、转移和预后等明显相关。旨在总结RCC相关lncRNA最新研究进展,浅析lncRNA在RCC发生、发展中的潜在分子机制,为RCC的预防、早期诊治及预后评估提供一种新的理论依据。

关键词: 长链非编码RNA, RCC, 靶向治疗

Abstract: Long non-coding RNA (lncRNA) is a class of RNA molecules, transcripted by RNA polymerase Ⅱ, which consists of more than 200 nucleotides and protein-coding function. Many studies have indicated that lncRNA plays an important role in epigenetics, transcription and post-translational processing. The abnormal expression of lncRNA significantly correlates with occurence, development, and metastasis of renal cell carcinoma (RCC) and prognosis of the patients with RCC. This paper summarizes the advances in the research on lncRNA in RCC to reveal the mechanisms of the disease at the molecular level, in order to provide new methods of prevention, diagnosis, treatment and prognostic assessment of RCC.

Key words: Long non-coding RNA, Renal cell carcinoma, Targeted therapy