Abstract: Waldeyer’s ring is a circular band of lymphoid tissue which is mainly composed of nasopharynx, oropharynx, tonsils, tongue base and hypopharynx. It is the most common site of non-Hodgkin’s lymphoma (NHL) in the head and neck, and the most common histologic subtype is diffuse large B-cell lymphoma (DLBCL). Because of the special anatomical structure, primary Waldeyer’s ring NHL has some unique clinical features. The diagnosis and treatment can partially refer to other nodal NHL. According to the literature reported in the past years, the international prognostic index (IPI), performance status (PS), age, stage, pathological type, treatment options may impact on the prognosis of the patients. Patients with limited stage could be treated with local radiotherapy. Systematic chemotherapy is widely used in patients with extensive stage. At present, for the patients with localized Waldeye's ring DLBCL, R-CHOP is the standard treatment, but there is no consensus about whether they should receive radiotherapy after immunochemotherapy. Due to the development of systematic treatment, whether subsequent radiotherapy can be omitted for patients with localized disease, especially for patients who have achieved complete response after immunochemotherapy, will become an important research topic.

Key words: Non-Hodgkin’s lymphoma, Waldeyer’s ring, Clinical characteristics, Prognosis, Therapy