Abstract: Background and purpose: Although incidence rate of early glottic cancer is not high, this disease has a significant impact on patients’ language function and quality of life. There are many surgical treatment methods for early glottic cancer, and various therapies have great differences in literature reports. We compared the curative effects of partial laryngectomy and endoscopic CO ₂ laser microsurgery in patients with combined positive early glottic cancer before treatment. Methods: From Nov. 2015 to May 2018, 128 patients with pre-combined positive early glottic cancer were divided into two groups according to odd or even dates of hospitalization, and according to the different treatment methods, the patients were divided into the experimental group (transoral endoscopic CO ₂ laser microsurgery) and the control group (partial laryngectomy). The scores of swallowing function and quality of life before and after treatment, acoustic indexes, clinical data and clinical efficacy before and after treatment were compared between the two groups. Results: After the treatment, Jitter and Shimmer indexes in the experimental group were significantly lower than those in the control group (P<0.05), and normalized noise energy (NNE) and harmonics to noise ratio (HNR) indexes in the experimental group were significantly higher than those in the control group (P<0.05). After treatment, standardized swallowing assessment (SSA) scores in the experimental group were significantly lower than those in the control group (P<0.05). The operative time and intraoperative blood loss of patients in the experimental group were significantly lower than those in the control group (P<0.05). Compared with the clinical efficacy between the two groups, the number of patients cured in the experimental group was significantly higher than that in the control group (P<0.05). Conclusion: Compared with traditional partial laryngectomy, transoral endoscopic CO ₂ laser microsurgery has a better curative effect on patients with early positive glottic cancer before treatment, which is helpful for the recovery of voice function and swallowing function.

Key words: Laryngectomy, CO ₂ laser, The glottis cancer, Comparative effectiveness