Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents

doi:10.19401/j.cnki.1007-3639.2022.05.003

Abstract

Abstract:

Background and purpose: Thyroid cancer is one of the fastest increasing malignancies worldwide, and its incidence in children and adolescents has also been increasing over the years. Meta-analysis were performed to investigate the correlation between gene alteration patterns and distant metastasis of differentiated thyroid carcinoma (DTC) in children and adolescents. Methods: Databases were used to search studies on the association between gene alteration patterns and distant metastasis of DTC in children and adolescents, and STATA 14.0 software was used to analyze the gene alterations related to distant metastasis. Results: Twenty studies involving 1 273 patients were included, and the analysis showed that negative BRAF V600E mutation and positive RET gene fusion were risk factors for distant metastasis in DTC in children and adolescents, while NTRK gene fusion was not significantly associated with distant metastasis. Conclusion: Our research identified several genetic alterations associated with distant metastasis in DTC in children and adolescents, which could be guidance for prognosis assessment and treatment planning.

Key words: Differentiated thyroid cancer, Children and adolescents, Distant metastasis, Gene mutation

CLC Number:

R736.1

DENG Shuting, FENG Yuan, QIAN Kai, GUO Kai, WANG Zhuoying. Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents[J]. China Oncology, 2022, 32(5): 388-396.

Figures/Tables 6

Fig. 1

Tab. 1

Characteristics of included studies"

Author	Published year	Country	Study period	Definition /year	Mean age (range)	Distant metastasis/total (%)	Surgical treatment (%)	RAI/%	Mean follow-up period t/year	Genetic events	Detection method	NOS quality
Sui^[16]	2019	China	2005-2018	≤20	14.54±4.43	40/69 (57.8)	TT (100.0)	100	2.7	BRAF	NR	M
Zhao^[17]	2020	China	2007-2019	≤20	NR	10/77 (13.0)	NR	NR	NR	BRAF	DS	M
Geng^[18]	2019	China	2000-2015	≤14	7.05±1.65	6/39 (15.4)	NR	NR	NR	BRAF	DS	M
Cordioli^[15]	2016	Brazil	1993-2012	≤18	11.36±4.52	10/30 (33.3)	TT (100.0)	NR	NR	AGK-BRAF	RT-PCR	M
Sisdelli^[13]	2019	Brazil	1993-2017	≤18	12.64±4.08	24/80 (30.0)	TT (100.0)	NR	NR	AGK-BRAF	RT-PCR, FISH	M
										BRAF	DS
Chakraborty^[6]	2020	India	2005-2018	≤20	17.00 (14.0-19.0)	17/95 (17.9)	TT (83.2)	33.7	2.5	BRAF	DS	M
							HT (16.8)
Givens^[19]	2014	America	1999-2012	≤18	13.55±3.33	5/19 (26.3)	TT (100.0)	NR	NR	BRAF	Pyrosequencing	H
Geng^[20]	2018	China	1994-2014	≤18	(3.6-13.8)	7/48 (14.6)	TT (56.3)	NR	NR	BRAF	DS	M
							HT (43.7)
Onder^[21]	2016	Turkey	1995-2015	≤18	14.74±3.36	5/50 (10.0)	TT (100.0)	76.0	5.8	BRAF	MASA-PCR	H
Geng^[57]	2019	China	NR	≤18	NR	7/48 (14.6)	TT (56.3)	NR	NR	TERT	DS	L
							HT (43.7)
Stosic^[22]	2021	Canada	NR	≤18	12.80±2.90	11/52 (21.2)	NR	NR	NR	BRAF	MASA-PCR	H
										RET	q-PCR
Franco^[23]	2022	America	1989-2019	≤18	14.53±2.99	22/131 (16.8)	TT (100.0)	65.6	NR	RET	NGS	M
										NTRK
										BRAF
										RAS
Cordioli^[12]	2017	Brazil	NR	≤18	11.80±4.48	13/35 (37.1)	TT (100.0)	NR	NR	BRAF	DS	H
										NTRK	RT-PCR
										AGK-BRAF	RT-PCR, FISH
										RET	RT-PCR
Alzahrani^[24]	2020	Saudi	2004-2019	≤18	17.00 (5.0-18.0)	5/48(10.4)	TT (100.0)	89.6	10.8	BRAF	NGS	M
										RET
Potter^[25]	2021	America	2005-2016	≤24	NR	10/36 (27.8)	NR	94.0	NR	BRAF	NGS	M
										RET
										NTRK
Lee^[26]	2021	Korea	1983-2020	≤20	14.30±3.80	20/106 (18.9)	NR	NR	7.3	RET	Various methods	M
										NTRK
										ALK
										BRAF
Pekova^[27]	2020	Czech	2003-2019	≤20	14.50±3.40	10/93 (10.8)	TT (88.2)	90.3	6.0	RET	NGS,RT-PCR	M
							ST (11.8)			NTRK
										ALK
										BRAF
Alzahrani^[28]	2017	Saudi	1998-2015	≤18	15.50 (8.0-18.0)	9/79 (11.4)	TT (100.0)	92.4	5.4	BRAF	DS	M
Pekova^[29]	2019	Czech	2003-2017	≤20	14.2±3.4	10/83 (12.0)	TT (86.7)	86.7	6.0	RET	RT-PCR	H
							HT (13.3)			BRAF	NGS
Alzahrani^[30]	2016	Saudi	NR	≤18	16.00 (9.0-18.0)	8/55 (14.5)	TT (100.0)	89	NR	BRAF	DS	M

Tab. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

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