Abstract:

Background and purpose: Primary hepatic carcinoma is a high incidence malignant tumor in China, and the prognosis is poor. The study aimed to investigate the prognostic influencing factors and the effects of different treatments by analyzing Uyghur patients with primary hepatic carcinoma treated in our hospital. Methods: We retrospectively analyzed the clinical data of 246 Uyghur patients with primary hepatic carcinoma. Kaplan-Meier method was used to calculate survival rate, univariate analysis by log-rank test was used to determine the prognostic influencing factors, and multivariate analysis by Cox proportional hazard model was used to determine the independent factors of prognosis. Results: The median survival time of the 246 patients was 10.7 months. The 1-, 2-, 3-, 4-, and 5-year survival rates were 41.97%, 22.13%, 14.87% and 8.92% respectively. The multivariate analysis indicated that age (P=0.003), tumor staging (P=0.000), portal cancerous thrombus (P=0.000), Child-Pugh grading (P=0.000) and levels of serum LDH (P=0.000) were independent prognostic factors influencing survival. The median survival time of patients treated by surgery, TACE, chemoradiation or RFA was 19.2 months, which was only 9.1 months for the supportive therapy group. The efficacy of combined therapeutic group was better than that of single treatment group. Conclusion: The independent prognosis factors included age, neoplasm staging, portal vein cancerous thrombus, Child-Pugh grading and levels of serum LDH in Uyghur patients with primary hepatic carcinoma. The therapeutic efficacy of surgery, TACE, chemoradiation and RFA are significantly better than that of support therapy, combined therapy is better than that of single therapy.

Key words: Uyghur, Primary hepatic carcinoma, Prognostic factors, Therapeutic efficacy