Abstract: Background and purpose: The morbidity rate of endometrial cancer is increasing in young patients these years. Fertility-sparing treatment with progesterone was concerned. The objective of this study was to evaluate the efficacy and safety of fertility-sparing treatment with progesterone in young patients with early endometrial carcinoma. Methods: The data of 19 early endometrial cancer patients fertility-sparing treatment with progestin was reviewed. These patients were treated and followed up at Zhejiang Cancer Hospital and Zhejiang Women’s Hospital from 2002 to 2014. Results: After primary treatment, 68.4% of patients achieved complete response. The recurrence rate was approximately 15.4% in a median follow-up period of 87.9 months, 46.2% of the patients succeed in giving birth. Conclusion: Fertility-sparing treatment with progesterone is an effective method to preserve fertility for early endometrial cancer patients. But it has inherent risks, comparing with the traditional treatment.

Key words: Endometrial carcinoma, Progesterone, Fertility-sparing treatment