Abstract:

Background and purpose: Colorectal serrated adenoma (SA) was officially named in 2000 by the WHO as a separate disease, with unique properties compared with traditional adenoma (TA), and its relationship with colorectal cancer (CRC) is very concerned. This study was to analyze and compare the telomerase, p53 and Ki-67 immunohistochemical expression on the tissues of SA, TA and CRC. Methods: Immunohistochemistry was adopted to analyze the expression of telomerase, p53, and Ki-67 in 37 cases of SA, 36 cases of TA and 34 cases of CRC. Results: The p53-positive percentage of SA was significantly lower than that of TA (P<0.01), and the p53-positive percentage of TA was significantly lower than that of CRC (P<0.01). No significant difference of Ki-67 expression was found between SA and TA, and the Ki-67-positive percentage of SA and TA was lower than that of CRC (P<0.01). The telomerasepositive percentage of TA was significantly lower than that of SA (P<0.01), and the telomerase-positive percentage of SA was significantly lower than that of CRC (P<0.05). Conclusion: Telomerase, P53, and Ki-67 immunohisto chemical analysis indicated that SA is a kind of proliferative adenoma, and telomerase activation may play a role in the cancer process.

Key words: Serrated adenoma, Traditional adenoma, Telomerase, p53, Ki-67