China Oncology ›› 2022, Vol. 32 ›› Issue (4): 357-362.doi: 10.19401/j.cnki.1007-3639.2022.04.009
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ZHOU Changshuai1()(), YANG Yuechao1, CUI Huanhuan1, CHEN Lei1, CHEN Xin1, HAO Bin1, TONG Tong2, CAO Yiqun1()()
Received:
2022-01-19
Revised:
2022-02-20
Online:
2022-04-30
Published:
2022-05-07
Contact:
CAO Yiqun
E-mail:zhoucs1682@163.com;gem23@163.com
CLC Number:
ZHOU Changshuai, YANG Yuechao, CUI Huanhuan, CHEN Lei, CHEN Xin, HAO Bin, TONG Tong, CAO Yiqun. Prognostic factor analysis of surgical treatment for cerebellar metastases in 36 patients[J]. China Oncology, 2022, 32(4): 357-362.
Tab. 1
Clinicopathological features of 36 patients with cerebellar metastases"
Factors | n=36 |
---|---|
Age/year | 58.75±8.99 |
Female | 16 (44.44%) |
Extracranial metastasis | 23 (63.89%) |
Lesions | |
1 | 18 (50.00%) |
2 | 10 (27.78%) |
≥3 | 8 (22.22%) |
Diameter D/cm | |
≥3 | 24 (66.67%) |
<3 | 12 (33.33%) |
Location | |
Cerebellar metastases | 19 (52.78%) |
Combined supratentorial metastases | 17 (47.22%) |
Peritumoral edema | |
Light | 16 (44.44%) |
Moderate | 11 (30.56%) |
Severe | 9 (25.00%) |
Primary tumor | |
Lung cancer | 19 (52.78%) |
Breast cancer | 7 (19.44%) |
Colorectal cancer | 4 (11.11%) |
Gynecological tumor | 2 (5.56%) |
Melanoma | 2 (5.56%) |
Renal carcinoma | 1 (2.78%) |
Pancreatic cancer | 1 (2.78%) |
Ki-67 proliferation index | |
<50% | 15 (41.67%) |
≥50% | 21 (58.33%) |
Postoperative targeted therapy | 18 (50.00%) |
Postoperative radiotherapy | 20 (55.56%) |
Tab. 2
Univariate and multivariate Cox regression analysis of 36 cases of cerebellar metastases"
Characteristics | Case (n=36) | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
Age (≥65 years) | 9 | 1.838 (0.727-4.646) | 0.198 | ||
Gender (male) | 20 | 1.854 (0.747-4.606) | 0.183 | ||
Extracranial metastasis | 23 | 1.696 (0.656-4.384) | 0.276 | ||
KPS score≥70 | 24 | 0.767 (0.316-1.865) | 0.559 | ||
Diameter ≥3 cm | 24 | 0.739 (0.287-1.904) | 0.531 | ||
Multiple lesions (≥3) | 8 | 3.393 (1.371-8.400) | 0.008 | 2.079 (0.516-8.375) | 0.303 |
Combined supratentorial metastases | 17 | 2.334 (0.949-5.739) | 0.065 | 1.517 (0.432-5.332) | 0.515 |
Peritumoral edema (severe) | 9 | 0.524 (0.166-1.659) | 0.272 | ||
Postoperative radiotherapy | 20 | 0.262 (0.106-0.648) | 0.004 | 0.040 (0.008-0.196) | <0.001 |
Postoperative targeted therapy | 18 | 0.321 (0.122-0.846) | 0.022 | 0.178 (0.052-0.602) | 0.006 |
Ki-67 proliferation index ≥50% | 21 | 3.543 (1.255-10.002) | 0.017 | 3.772 (1.067-13.336) | 0.039 |
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