Abstract: Sustaining survival of tumor cells is the main limiting step of tumor metastasis. Similar to tumor microenvironment, local environment in premetastatic organ (premetastatic niche) also provides a favorable condition for surviving of tumor cell and is the premise of tumor cell survival and proliferation in distant organ. Myeloid-derived suppressor cells (MDSCs) are the key component of the niche and play an important role in tumor cell implantation and metastasis formation through fabricating a proliferative, inflammatory, immunosuppressive and vascular remodeling premetastatic niche. MDSCs may also serve as potential therapeutic target for anti-metastasis therapy. Here, this study focused on the mechanisms of MDSCs in prematastatic niche formation and associated signal pathway, moreover, provided reference to study on anti-metastasis therapy through interfering with the formation of premetastatic niche.

Key words: Myeloid-derived suppressor cells, Premetastatic niche, Tumor metastasis