Abstract: Background and purpose: Fallopian tube carcinoma is a rare malignant tumor of gynecology with a poor prognosis. In this paper, the clinical and pathological factors affecting the prognosis of fallopian tube carcinoma were analyzed retrospectively. Methods: Effects of clinical and pathological factors on prognosis in 62 patients with fallopian tube carcinoma were retrospectively evaluated. Kaplan-Meier method was used to calculate the survival time, and log-rank test was used for comparison between groups. COX proportional hazards model was used to analyze the significant factors of single factor analysis. Results: The median survival time of 62 patients with fallopian tube carcinoma was 74 months, the 3-year survival rate was 78% and the 5-year survival rate was 63%. International Federation of Gynaecology and Obstetrics (FIGO) stage, postoperative residual tumor size, and number of courses of chemotherapy were the independent prognostic factors in patients with fallopian tube carcinoma. The median survival time, 3-year and 5-year survival rates of P53-negative patients were higher than those of P53-positive patients. The average ratio of Ki-67 was 58.41%, and the median survival time, 3-year and 5-year survival rates of patients with Ki- 67≤58% numerically were higher than those of patients with Ki-67>58%. Conclusion: FIGO stage, postoperative residual tumor size, and number of courses of chemotherapy are the independent prognostic factors in patients with fallopian tube carcinoma. Early diagnosis and early treatment are the key factors to improve the prognosis. Striving for the greatest degree of thoroughness of cytoreductive surgery, followed by an effective and full course of chemotherapy, can improve the survival rate of patients with fallopian tube carcinoma. Pathological examinations, especially the expression levels of p53 protein and Ki-67, have a certain significance in judging the prognosis of fallopian tube carcinoma.

Key words: Fallopian tube carcinoma, Clinical, Pathology, Prognosis