关键词: 去泛素化, 肿瘤, 凋亡, 信号传导, 细胞周期

Abstract:

Deubiquitinating enzymes, reversing protein ubiquitination, most of the researches focused on the field of molecular biology. However, it have not yet attracted enough attention in translational medicine research. In fact, target proteins of deubiquitinating enzymes affect the tumor progression through various ways, for example, cell apoptosis and autophagy, the link between inflammation and cancer, tumor hypoxia, signal transduction, cell cycle regulation and DNA damage. This paper reviewed the research progress on the relations between deubiquitinating enzymes and the correlated factors of tumor.

Key words: Deubiquitination, Neoplasms, Apoptosis, Signal transduction, Cell cycle