关键词: 遗传性大肠癌综合征, 研究进展, 中国

Abstract: Both the incidence and mortality of colorectal cancer in China are increasing year by year. Hereditary colorectal cancer accounts for about 5%-6% of all the colorectal cancer cases, which is caused by hereditary colorectal cancer syndromes. The risk of colorectal cancer in hereditary colorectal cancer syndrome patients is significantly higher than that in general population. Fortunately, early screening and management can largely reduce cancer risk in these patients. Here, we summarize clinical and genetic features of Chinese hereditary colorectal cancer syndromes including Lynch syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome, and review the guidelines for diagnosis and treatment in China and abroad. This paper may help people better understand hereditary colorectal cancer syndromes and facilitate accurate diagnosis and early treatment.

Key words: Hereditary colorectal cancer syndromes, Research progress, China