中国癌症杂志 ›› 2017, Vol. 27 ›› Issue (4): 304-311.doi: 10.19401/j.cnki.1007-3639.2017.04.011

• 综述 • 上一篇    下一篇

甲状腺癌的DNA甲基化研究进展

曹一鸣 综述,朱永学 审校   

  1. 复旦大学附属肿瘤医院头颈外科,复旦大学上海医学院肿瘤学系,上海 200032
  • 出版日期:2017-04-30 发布日期:2017-05-05
  • 通信作者: 朱永学 E-mail: zhuyongxue163@126.com
  • 基金资助:
    上海市自然科学基金资助项目(12ZR1406800)。

Research progress of DNA methylation in thyroid cancer

CAO Yiming, ZHU Yongxue   

  1. Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • Published:2017-04-30 Online:2017-05-05
  • Contact: ZHU Yongxue E-mail: zhuyongxue163@126.com

摘要: DNA甲基化是一种重要的表观遗传学改变,在肿瘤的发病、诊断、预后评估及治疗中都有重要的临床意义。甲状腺癌是临床最常见的内分泌系统恶性肿瘤,目前国内外关于甲状腺癌的DNA甲基化的研究相对较少,该文总结近年来甲状腺癌领域相关的基因甲基化研究,就甲状腺癌的DNA甲基化研究进展进行综述。

关键词: 甲状腺癌, 表观遗传学, DNA甲基化

Abstract: DNA methylation is an important epigenetic modification. Evaluating the status of DNA methylation could be useful for diagnosis, prognostic evaluation and predicting the risk of cancer. Thyroid cancer is the most prevalent endocrine malignancy in humans. Growing evidence shows that epigenetic abnormalities participate with genetic alterations in carcinogenesis of thyroid cancer. This article reviewed the recent research progress of DNA methylation in thyroid cancer.

Key words: Thyroid cancer, Epigenetics, DNA methylation