Abstract: Background and purpose: Lung cancer is one of the leading causes of cancer death in the world. The aim of this study was to evaluate whether Fas-670 G>A and Fasl-844 T>C polymorphisms were associated with the risk of lung cancer. Methods: Data from 400 lung cancer patients with specific histological diagnosis were collected from 2010 to 2015. Meanwhile, data from matched healthy controls with the same gender and ±5 years were also collected. The genotypes of Fas-670 G>A and Fasl-844 T>C polymorphisms were determined by TaqMan fluorescent probe method, and the results were analyzed using SPSS 16.0 software. Results: A total number of 386 cases and 394 controls were successfully genotyped. Compared with AA genotype of Fas gene, the GA and GG genotype carriers had no significantly increased risk of lung cancer. The OR values were 1.05 (95%CI: 0.77-1.44) and 0.77 (95%CI: 0.81-1.99) respectively. Compared with TT genotype of Fasl gene, the CT and CC genotype carriers had significantly increased risk of lung cancer. The OR values were 1.37 (95%CI: 1.01-1.86) and 1.74 (95%CI: 1.09-2.77), respectively. Conclusion: Fasl-844 T>C polymorphism may be involved in lung cancer risk but not Fas-670 G>A polymorphism.

Key words: Fas gene, Fasl gene, Polymorphism, Lung cancer, Susceptibility