Abstract: Colorectal cancer is one of the most common cancers in the world with high morbidity and mortality. Clinicians spare no effort to look for effective prevention and treatment strategies for colorectal cancer. Research shows that aspirin plays a unique role in colorectal cancer prevention and treatment. However, the effect is associated with the course of treatment, users’ genetic backgrounds and some other factors. This review aimed to summarize the prevention and treatment effects of aspirin on colorectal cancer, the possible molecular markers for predicting aspirin efficacy and related mechanisms.

Key words: Colorectal neoplasms, Drug therapy, Aspirin