China Oncology ›› 2014, Vol. 24 ›› Issue (9): 669-675.doi: 10.3969/j.issn.1007-3969.2014.09.005

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Relationship between single nucleotide polymorphisms in 2q35 rs13387042 and 8q24 rs13281615 and breast cancer risk of Han premenopausal women in Northern China

BAI Xia-nan, JIANG Yong-dong, LIU Tong, WU Hao, ZHANG Jin-feng, PANG Da   

  1. Department of Breast Surgery of the Third Affiliated Hospital, Harbin Medical University, Harbin Heilongjiang 150086, China
  • Online:2014-09-30 Published:2014-11-12
  • Contact: PANG Da E-mail: pangdasir@163.com

Abstract:

Background and purpose: Breast cancer as one of the most common malignant tumor among women in China, it accounts for 12.2% of all newly diagnosed breast cancers and 9.6% of all deaths from breast cancer worldwide. The aim of this study was to investigate the relationship between single nucleotide polymorphisms(SNPs) in 2q35 rs13387042 and 8q24 rs13281615 and the risk of breast cancer in Han premenopausal women of Northern China. Methods: 280 patients with breast cancer and 287 healthy controls in premenopausal state were genotyped for SNP 2q35 rs13387042 and 8q24 rs13281615 by the SNaPshot method, and compared the different genotypes and alleles with relation to breast cancer risk. Results: Differences of 2q35 rs13387042 genotype frequencies between breast cancer and control were significantly different (P=0.017). No statistically significant difference of 8q24 rs13281615 genotype frequencies between breast cancers and controls was found (P=0.967). The results of logistic regression showed that the carriers of GA genotype and GA+ AA genotype increased risk for breast cancer compared to the carriers with 2q35 rs13387042 GG genotype(OR=1.793, 95%CI: 1.177-2.733, P=0.007OR=1.691, 95%CI: 1.122-2.550, P=0.012), but not the carriers of AA genotype; Compared with G allele, A allele significantly increased the risk of breast cancer(OR=1.505, 95%CI: 1.033-2.193, P=0.033). The carriers of AG genotype or GG genotype or AG+GG genotype did not confer risk for breast cancer compared to the carriers with 8q24 rs13281615 AA genotype(OR=0.992, 95%CI: 0.660-1.490, P=0.968; OR=1.047, 95%CI: 0.642-1.708, P=0.853; OR=1.007, 95%CI: 0.682-1.487, P=0.971); Compared with A allele, G allele did not increase the risk of breast cancer(OR=1.021, 95%CI: 0.809-1.288, P=0.863). Conclusion: This experiment verified that 2q35 rs13387042 polymorphism site increased risk of breast cancer susceptibility among Han premenopausal women of Northern China. There was not any significant association between 8q24 rs13281615 polymorphism site and breast cancer susceptibility among Han premenopausal women of Northern China under the current sampling scale.

Key words: Breast neoplasms, Single nucleotide polymorphism, Genetic susceptibility, 2q35 rs13387042, 8q24 rs13281615