The mechanism of Notch3 mediated progression of ovarian cancer

doi:10.3969/j.issn.1007-3969.2013.12.012

China Oncology ›› 2013, Vol. 23 ›› Issue (12): 1001-1006.doi: 10.3969/j.issn.1007-3969.2013.12.012

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The mechanism of Notch3 mediated progression of ovarian cancer

LIU Yang¹,YANG Gong²,ZANG Rong-yu¹

1.Departement of Gynecological Oncology, Fudan University Shanghai Cancer Center,Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China;
2.Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College,Fudan University, Shanghai 200032, China

Online:2013-12-30 Published:2014-02-17
Contact: ZANG Rong-yu E-mail: ryzang@yahoo.com

Abstract

Abstract: Notch signal pathway is one of crucial pathways related to cell fate determination, regulating cell differentiation, proliferation and apoptosis, with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells, such as brain tumors, breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ovarian cancer has been attracted extensive attention by experts and scholars.This review focuses on the literatures of Notch3 and related molecules regulating the development and progression of epithelial ovarian cancer.

Key words: Notch3, Epithelial ovarian cancer, Signaling pathway

LIU Yang,YANG Gong,ZANG Rong-yu. The mechanism of Notch3 mediated progression of ovarian cancer[J]. China Oncology, 2013, 23(12): 1001-1006.

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The mechanism of Notch3 mediated progression of ovarian cancer

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