Abstract: Follicular lymphoma (FL) is a neoplasm derived from follicular center B cells. The incidence rates of FL are highest in America and Western Europe, but are much lower in Asia and developing countries. FL mainly involves lymph nodes, and the patients usually present with painless enlargement of multiple lymph nodes. FL originating from extranodal sites is common in gastrointestinal tract, soft tissues, breast and ocular adnexa. Most patients have an indolent clinical course with a long survival, however, a subset of patients suffer from relapse or progression over years. We reviewed the prognostic factors of FL, in order to provide some theoretical guidance to clinical treatment.

Key words: Follicular lymphoma, Prognostic factor, Pathology