Abstract: Background and purpose: The Shanghai Municipal Center for Disease Control and Prevention provides annual updates on cancer occurrence and trends in Shanghai. This study aimed to investigate the cancer incidence and mortality in 2016 and their trends from 2002 to 2016 in Shanghai. Methods: Data of new cancer diagnoses and deaths from 2002 to 2016 were obtained from the Shanghai Municipal Center for Disease Control and Prevention population-based cancer registry and Vital Statistics System. Cancer incidence and mortality stratified by year of diagnosis or death, gender and age group were analyzed. Number, proportion, crude rate, age-specific rate, age-standardized rate and others were calculated. The number, proportion and rates of common cancers in different groups were also calculated. Trends in age-standardized rate of incidence and death rates for all cancers combined and for the common cancer types by gender were estimated by joinpoint analysis and characterized by the annual percent change (APC). Segi’s 1960 world standard population was used for calculating age-standardized incidence and mortality. Results: The new cancer cases and deaths were 74 422 and 37 010 in Shanghai in 2016. The crude rate of incidence was 513.94/10 5 , and the age-standardized rate was 231.58/10 5 . The age-standardized rate of incidence was higher among females than among males. The crude rate of mortality was 255.58/10 5 , and the age-standardized rate was 90.01/10 5 . The age-standardized rate of mortality was higher among males than among females. The age-specific numbers and rates of incidence and mortality increased with age. The age-specific number and rate of incidence reached the peak at the age groups of 60-64 years and 80-84 years, and those of mortality reached the peak at the age groups of 80-84 years and more than 85 years, respectively. The sites of top 10 common cancer types sorted by the number of incidence cases were lung, colorectum, thyroid, stomach, breast, liver, prostate, pancreas, brain and central nervous system and bladder. The sites of those sorted by the number of mortality deaths were lung, colorectum, stomach, liver, pancreas, breast, gallbladder, esophagus, prostate and lymphoma. The top 10 common cancer types stratified by gender and the top 5 common cancer types stratified by common age groups merged of incidence and mortality had wide variations. Overall, the age-standardized rates of incidence among males were stable from 2002 to 2009, and increased 1.16% on average per year from 2009 to 2016. Those among females were stable from 2002 to 2009, and increased 4.48% on average per year from 2009 to 2016. The age-standardized rates of mortality among males decreased 1.35% on average per year, and those among females decreased 1.31% on average per year from 2002 to 2016. The trends differed by gender and cancer type. Conclusion: Although the age-standardized rates of cancer incidence were increasing slightly among males and females, those of cancer mortality were decreasing. These current status and trends of overall and common cancer types stratified by gender or age reflect Shanghai permanent population changes in cancer risk factors, screening test use, diagnostic practices and treatment advances. Population-based cancer incidence and mortality data can be used to inform efforts to decrease the cancer burden.

Key words:  Cancer, Incidence, Mortality, Trends, Shanghai